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dc.contributor.author | Tamaoki, Masashi | en |
dc.contributor.author | Komatsuzaki, Rie | en |
dc.contributor.author | Komatsu, Masayuki | en |
dc.contributor.author | Minashi, Keiko | en |
dc.contributor.author | Aoyagi, Kazuhiko | en |
dc.contributor.author | Nishimura, Takao | en |
dc.contributor.author | Chiwaki, Fumiko | en |
dc.contributor.author | Hiroki, Tomoko | en |
dc.contributor.author | Daiko, Hiroyuki | en |
dc.contributor.author | Morishita, Kazuhiro | en |
dc.contributor.author | Sakai, Yoshiharu | en |
dc.contributor.author | Seno, Hiroshi | en |
dc.contributor.author | Chiba, Tsutomu | en |
dc.contributor.author | Muto, Manabu | en |
dc.contributor.author | Yoshida, Teruhiko | en |
dc.contributor.author | Sasaki, Hiroki | en |
dc.contributor.alternative | 坂井, 義治 | ja |
dc.contributor.alternative | 妹尾, 浩 | ja |
dc.contributor.alternative | 千葉, 勉 | ja |
dc.contributor.alternative | 武藤, 学 | ja |
dc.date.accessioned | 2018-04-17T08:03:14Z | - |
dc.date.available | 2018-04-17T08:03:14Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | http://hdl.handle.net/2433/230647 | - |
dc.description.abstract | Degree of histological differentiation is an important characteristic of cancers and may be associated with malignant potential. However, in squamous cell carcinomas, a key transcriptional factor regulating tumor differentiation is largely unknown. Chemoradiotherapy (CRT) is a standard treatment for locally advanced esophageal squamous cell carcinoma; however, the survival rate is still below 40%. From microarray data, single‐minded 2 (SIM2) was overexpressed in the epithelial subtype. Here, we investigated the correlation between SIM2 expression and its clinical implication, and in vitro and in vivo functions of SIM2 in tumor differentiation and in CRT sensitivity. Although SIM2 was suppressed in cancerous tissues, SIM2‐high ESCC showed a favorable prognosis in CRT. Transient SIM2 expression followed by 3D culture induced expression of differentiation markers and suppressed epithelial‐mesenchymal transition‐ and basal‐cell markers. Levels of PDPN‐high tumor basal cells and of expression of genes for DNA repair and antioxidant enzymes were reduced in stable transfectants, and they showed high CDDP and H2O2 sensitivities, and their xenografts showed a well‐differentiated histology. Reduction of tumor basal cells was restored by knockdown of aryl hydrocarbon receptor nuclear translocator (ARNT) that interacted with SIM2. Together, SIM2 increases CRT sensitivity through tumor differentiation by cooperation with ARNT. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | en |
dc.rights | © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. | en |
dc.subject | ARNT | en |
dc.subject | chemoradiotherapy | en |
dc.subject | differentiation | en |
dc.subject | esophageal squamous cell carcinoma | en |
dc.subject | SIM2 | en |
dc.title | Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cancer Science | en |
dc.identifier.volume | 109 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1121 | - |
dc.identifier.epage | 1134 | - |
dc.relation.doi | 10.1111/cas.13531 | - |
dc.textversion | publisher | - |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Department of Clinical Trial Promotion, Chiba Cancer Center | en |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Department of Translational Oncology, National Cancer Center・Department of Gastrointestinal Surgery, Kyoto University Graduate School of Medicine | en |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Department of Translational Oncology, National Cancer Center | en |
dc.address | Esophageal Surgery Division, National Cancer Center, Tokyo | en |
dc.address | Department of Medical Sciences, University of Miyazaki | en |
dc.address | Department of Gastrointestinal Surgery, Kyoto University Graduate School of Medicine | en |
dc.address | Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine | en |
dc.address | Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine | en |
dc.address | Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine | en |
dc.address | Fundamental Innovative Oncology Core Center, National Cancer Center, Tokyo | en |
dc.address | Department of Translational Oncology, National Cancer Center, Tokyo | en |
dc.identifier.pmid | 29427302 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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