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dc.contributor.author | Egawa, Gyohei | en |
dc.contributor.author | Kabashima, Kenji | en |
dc.contributor.alternative | 江川, 形平 | ja |
dc.contributor.alternative | 椛島, 健治 | ja |
dc.date.accessioned | 2018-04-23T02:28:59Z | - |
dc.date.available | 2018-04-23T02:28:59Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1323-8930 | - |
dc.identifier.uri | http://hdl.handle.net/2433/230801 | - |
dc.description.abstract | The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.subject | Atopic dermatitis | en |
dc.subject | Barrier function | en |
dc.subject | Cornified envelope | en |
dc.subject | Stratum corneum | en |
dc.subject | Tight junction | en |
dc.title | Barrier dysfunction in the skin allergy | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Allergology International | en |
dc.identifier.volume | 67 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 3 | - |
dc.identifier.epage | 11 | - |
dc.relation.doi | 10.1016/j.alit.2017.10.002 | - |
dc.textversion | publisher | - |
dc.address | Department of Dermatology, Kyoto University Graduate School of Medicine | en |
dc.address | Department of Dermatology, Kyoto University Graduate School of Medicine・Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR)・PRESTO, Japan Science and Technology Agency | en |
dc.identifier.pmid | 29153780 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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