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タイトル: 長期経過観察で診断しえた転移・再発を有する腎Mucinous Tubular and Spindle Cell Carcinoma(MTSCC)の2例
その他のタイトル: Two Cases of Metastatic and Recurrent Non-Clear Cell Renal Cell Carcinoma Re-Diagnosed as Renal Mucinous Tubular and Spindle Cell Carcinoma during Long-Term Follow-Up
著者: 久保田, 聖史  KAKEN_name
山崎, 俊成  KAKEN_name
寺本, 祐記  KAKEN_name
伊藤, 克弘  KAKEN_name
高田, 秀明  KAKEN_name
曲淵, 敏博  KAKEN_name
澤田, 篤郎  KAKEN_name
赤松, 秀輔  KAKEN_name
根来, 宏光  KAKEN_name
齋藤, 亮一  KAKEN_name
小林, 恭  KAKEN_name
寺田, 直樹  KAKEN_name
井上, 貴博  KAKEN_name
神波, 大己  KAKEN_name
小川, 修  KAKEN_name
著者名の別形: Kubota, Masashi
Yamasaki, Toshinari
Teramoto, Yuki
Ito, Katsuhiro
Takada, Hideaki
Magaribuchi, Toshihiro
Sawada, Atsuro
Akamatsu, Shusuke
Negoro, Hiromitsu
Saito, Ryoichi
Kobayashi, Takashi
Terada, Naoki
Inoue, Takahiro
Kamba, Tomomi
Ogawa, Osamu
キーワード: Renal mucinous tubular and spindle cell carcinoma
Renal cell carcinoma
発行日: 31-Mar-2018
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要 = Acta urologica Japonica
巻: 64
号: 3
開始ページ: 111
終了ページ: 115
抄録: Renal mucinous tubular and spindle cell carcinoma (MTSCC) is a rare, low-grade renal epithelial neoplasm. MTSCC has a lower malignant potential and shows relatively good prognosis, but can be difficult to distinguish from other renal cell carcinoma (RCC) subtypes. Here, we report two cases of metastatic and recurrent renal MTSCC diagnosed after long-term follow-up. Case 1 was a 79-year-old man with a history of macroscopic hematuria in whom a right kidney mass was detected and diagnosed as RCC (cT3bN0M0). After a radical nephrectomy, microscopic findings showed that the tumor consisted of spindle cells arranged in tubular patterns embedded in sarcomatoid tissues ; we diagnosed it as unclassified RCC with sarcomatoid differentiations (pT3aN0M0). Thereafter, metastases were twice detected and resected completely. The patient had no evidence of disease at his most recent follow-up, 10 years 1 month after the initial surgery. Case 2 was in a 72-year-old man in whom a right kidney mass, swollen lymph nodes, and a lung node were incidentally detected. This tumor was diagnosed as RCC (cT4N2M1), and radical nephrectomy and lymph node dissections were carried out. From the microscopic findings, we diagnosed papillary RCC type-2 (pT3aN2M1). After the surgery, pleural and bone metastases was detected. Despite sequential treatments with IFN-α and sunitinib, the patient suffered indolent-growing metastases and died at 5 years 6 months after operation. As these patients had relatively good prognoses despite assumed aggressive RCC subtypes, we reviewed their pathological findings. In both cases, tumor samples showed tubules lined by short cuboidal cells that were set within myxoid stromata and spindle cells ; we finally diagnosed these cases as renal MTSCC.
著作権等: 許諾条件により本文は2019/04/01に公開
DOI: 10.14989/ActaUrolJap_64_3_111
URI: http://hdl.handle.net/2433/230901
PubMed ID: 29684960
出現コレクション:Vol.64 No.3

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