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dc.contributor.author | Park, Soyoung | en |
dc.contributor.author | Okamura, Izumi | en |
dc.contributor.author | Sakashita, Sohei | en |
dc.contributor.author | Yum, Ji Hye | en |
dc.contributor.author | Acharya, Chiranjit | en |
dc.contributor.author | Gao, Li | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | 朴, 昭映 | ja |
dc.contributor.alternative | 岡村, 和泉 | ja |
dc.contributor.alternative | 坂下, 宗平 | ja |
dc.contributor.alternative | 杉山, 弘 | ja |
dc.date.accessioned | 2018-04-27T05:16:47Z | - |
dc.date.available | 2018-04-27T05:16:47Z | - |
dc.date.issued | 2015-08-07 | - |
dc.identifier.issn | 2155-5435 | - |
dc.identifier.uri | http://hdl.handle.net/2433/230917 | - |
dc.description.abstract | We report here DNA metalloenzymes that catalyzed the asymmetric Diels-Alder reactions with high conversion, excellent endo/exo selectivities, and enantioselectivities up to -97% ee. Their catalytic-pocket architectures were organized using a rational design strategy based on the Cu(II) ion, the composition of nucleobases, and the incorporation of flexible linkers. Without using the mirror image of B-DNA, DNA metalloenzymes afforded the opposite enantiomer of the Diels-Alder product compared with those obtained using a supramolecular Cu(II)-dmbpy/st-DNA catalyst system. Furthermore, we devised DNA metalloenzymes without the incorporation of an artificial binding ligand and successfully performed Diels-Alder carbon-carbon bond-forming reactions. This study provides a new perspective on the catalytic repertoire of nucleic acids in the realm of protein-dominated metalloenzymes. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | en |
dc.rights | © 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acscatal.5b01046. The full-text file will be made open to the public on 07 August 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | asymmetric catalysis | en |
dc.subject | Cu(II) ion | en |
dc.subject | Diels-Alder reaction | en |
dc.subject | DNA | en |
dc.subject | enantiomeric preference | en |
dc.subject | ligand freedom | en |
dc.subject | metalloenzyme | en |
dc.title | Development of DNA Metalloenzymes Using a Rational Design Approach and Application in the Asymmetric Diels-Alder Reaction | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | ACS Catalysis | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 4708 | - |
dc.identifier.epage | 4712 | - |
dc.relation.doi | 10.1021/acscatal.5b01046 | - |
dc.textversion | author | - |
dc.address | Department of Chemistry, Graduate School of Science, Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science, Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science, Kyoto University | en |
dc.address | Department of Chemistry, Kyungpook National University | en |
dc.address | Department of Chemistry, CSIR-Indian Institute of Chemical Biology | en |
dc.address | Department für Chemie, Ludwig-Maximilians-Universität | en |
dc.address | Department of Chemistry, Graduate School of Science, Kyoto University・Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University | en |
dcterms.accessRights | open access | - |
datacite.date.available | 2016-08-07 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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