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タイトル: | Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus |
著者: | Kinoshita, Haruko Nishitani, Naoya Nagai, Yuma Andoh, Chihiro Asaoka, Nozomi Kawai, Hiroyuki Shibui, Norihiro Nagayasu, Kazuki https://orcid.org/0000-0002-7438-732X (unconfirmed) Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed) Nakagawa, Takayuki https://orcid.org/0000-0003-1890-0843 (unconfirmed) Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
著者名の別形: | 西谷, 直也 安藤, 千紘 淺岡, 希美 河合, 洋幸 永安, 一樹 白川, 久志 中川, 貴之 金子, 周司 |
キーワード: | ketamine serotonin microdialysis nicotinic acetylcholine receptors raphe |
発行日: | Mar-2018 |
出版者: | Oxford University Press (OUP) |
誌名: | The international journal of neuropsychopharmacology |
巻: | 21 |
号: | 3 |
開始ページ: | 305 |
終了ページ: | 310 |
抄録: | Background: Ketamine rapidly elicits antidepressive effects in humans and mice in which serotonergic activity is involved. Although α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) in the dorsal raphe nucleus plays a key role in the ketamine-induced prefrontal serotonin release, the source of cholinergic afferents, and its role is unclear. Methods: Prefrontal serotonin levels after ketamine injection were measured by microdialysis in rats. Electrolytic lesion of pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus was made with constant direct current. Results: Bilateral lesion of the pedunculopontine tegmental nucleus, but not laterodorsal tegmental nucleus, attenuated prefrontal serotonin release induced by systemic ketamine. Intra-pedunculopontine tegmental nucleus, but not intra-laterodorsal tegmental nucleus ketamine perfusion, increased prefrontal serotonin release. This increase was attenuated by intra-dorsal raphe nucleus injection of dihydro-β-erythroidine, an α4β2 nAChR antagonist, or NBQX, an AMPA receptor antagonist. Conclusions: These results suggest the ketamine-induced serotonin release in medial prefrontal cortex is mediated by cholinergic neurons projecting from pedunculopontine tegmental nucleus to dorsal raphe nucleus via α4β2 nAChRs. |
著作権等: | © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
URI: | http://hdl.handle.net/2433/231169 |
DOI(出版社版): | 10.1093/ijnp/pyy007 |
PubMed ID: | 29370396 |
出現コレクション: | 学術雑誌掲載論文等 |
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