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タイトル: Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus
著者: Kinoshita, Haruko
Nishitani, Naoya
Nagai, Yuma
Andoh, Chihiro
Asaoka, Nozomi
Kawai, Hiroyuki
Shibui, Norihiro
Nagayasu, Kazuki
Shirakawa, Hisashi  kyouindb  KAKEN_id
Nakagawa, Takayuki
Kaneko, Shuji  kyouindb  KAKEN_id
著者名の別形: 西谷, 直也
安藤, 千紘
淺岡, 希美
河合, 洋幸
永安, 一樹
白川, 久志
中川, 貴之
金子, 周司
キーワード: ketamine
serotonin
microdialysis
nicotinic acetylcholine receptors
raphe
発行日: Mar-2018
出版者: Oxford University Press (OUP)
誌名: The international journal of neuropsychopharmacology
巻: 21
号: 3
開始ページ: 305
終了ページ: 310
抄録: Background: Ketamine rapidly elicits antidepressive effects in humans and mice in which serotonergic activity is involved. Although α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) in the dorsal raphe nucleus plays a key role in the ketamine-induced prefrontal serotonin release, the source of cholinergic afferents, and its role is unclear. Methods: Prefrontal serotonin levels after ketamine injection were measured by microdialysis in rats. Electrolytic lesion of pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus was made with constant direct current. Results: Bilateral lesion of the pedunculopontine tegmental nucleus, but not laterodorsal tegmental nucleus, attenuated prefrontal serotonin release induced by systemic ketamine. Intra-pedunculopontine tegmental nucleus, but not intra-laterodorsal tegmental nucleus ketamine perfusion, increased prefrontal serotonin release. This increase was attenuated by intra-dorsal raphe nucleus injection of dihydro-β-erythroidine, an α4β2 nAChR antagonist, or NBQX, an AMPA receptor antagonist. Conclusions: These results suggest the ketamine-induced serotonin release in medial prefrontal cortex is mediated by cholinergic neurons projecting from pedunculopontine tegmental nucleus to dorsal raphe nucleus via α4β2 nAChRs.
著作権等: © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
URI: http://hdl.handle.net/2433/231169
DOI(出版社版): 10.1093/ijnp/pyy007
PubMed ID: 29370396
出現コレクション:学術雑誌掲載論文等

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