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dc.contributor.author | Ueda, Norihiro | en |
dc.contributor.author | Uemura, Yasushi | en |
dc.contributor.author | Zhang, Rong | en |
dc.contributor.author | Kitayama, Shuichi | en |
dc.contributor.author | Iriguchi, Shoichi | en |
dc.contributor.author | Kawai, Yohei | en |
dc.contributor.author | Yasui, Yutaka | en |
dc.contributor.author | Tatsumi, Minako | en |
dc.contributor.author | Ueda, Tatsuki | en |
dc.contributor.author | Liu, Tian-Yi | en |
dc.contributor.author | Mizoro, Yasutaka | en |
dc.contributor.author | Okada, Chihiro | en |
dc.contributor.author | Watanabe, Akira | en |
dc.contributor.author | Nakanishi, Mahito | en |
dc.contributor.author | Senju, Satoru | en |
dc.contributor.author | Nishimura, Yasuharu | en |
dc.contributor.author | Kuzushima, Kiyotaka | en |
dc.contributor.author | Kiyoi, Hitoshi | en |
dc.contributor.author | Naoe, Tomoki | en |
dc.contributor.author | Kaneko, Shin | en |
dc.contributor.alternative | 上田, 格弘 | ja |
dc.contributor.alternative | 植村, 靖史 | ja |
dc.contributor.alternative | 喜多山, 秀一 | ja |
dc.contributor.alternative | 入口, 翔一 | ja |
dc.contributor.alternative | 河合, 洋平 | ja |
dc.contributor.alternative | 安井, 裕 | ja |
dc.contributor.alternative | 上田, 樹 | ja |
dc.contributor.alternative | 溝曽路, 祥孝 | ja |
dc.contributor.alternative | 岡田, 千尋 | ja |
dc.contributor.alternative | 渡辺, 亮 | ja |
dc.contributor.alternative | 中西, 真人 | ja |
dc.contributor.alternative | 千住, 覚 | ja |
dc.contributor.alternative | 西村, 泰治 | ja |
dc.contributor.alternative | 葛島, 清隆 | ja |
dc.contributor.alternative | 清井, 仁 | ja |
dc.contributor.alternative | 直江, 知樹 | ja |
dc.contributor.alternative | 金子, 新 | ja |
dc.date.accessioned | 2018-06-04T05:15:25Z | - |
dc.date.available | 2018-06-04T05:15:25Z | - |
dc.date.issued | 2018-06-05 | - |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | http://hdl.handle.net/2433/231323 | - |
dc.description | ヒトiPS細胞由来T細胞に遺伝子を導入すると、ヘルパーT細胞様の機能を獲得することを発見しました. 京都大学プレスリリース. 2018-06-04. | ja |
dc.description.abstract | CD4+ T helper (Th) cell activation is essential for inducing cytotoxic T lymphocyte (CTL) responses against malignancy. We reprogrammed a Th clone specific for chronic myelogenous leukemia (CML)-derived b3a2 peptide to pluripotency and re-differentiated the cells into original TCR-expressing T-lineage cells (iPS-T cells) with gene expression patterns resembling those of group 1 innate lymphoid cells. CD4 gene transduction into iPS-T cells enhanced b3a2 peptide-specific responses via b3a2 peptide-specific TCR. iPS-T cells upregulated CD40 ligand (CD40L) expression in response to interleukin-2 and interleukin-15. In the presence of Wilms tumor 1 (WT1) peptide, antigen-specific dendritic cells (DCs) conditioned by CD4-modified CD40Lhigh iPS-T cells stimulated WT1-specific CTL priming, which eliminated WT1 peptide-expressing CML cells in vitro and in vivo. Thus, CD4 modification of CD40Lhigh iPS-T cells generates innate lymphoid helper-like cells inducing bcr-abl-specific TCR signaling that mediates effectiveanti-leukemic CTL responses via DC maturation, showing potential for adjuvant immunotherapy against leukemia. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.subject | iPSCs | en |
dc.subject | T cell differentiation | en |
dc.subject | innate lymphoid cells | en |
dc.subject | immuno-adjuvant function | en |
dc.subject | bcr-abl | en |
dc.subject | CD40L | en |
dc.subject | DC activation | en |
dc.subject | chronic myeloid leukemia | en |
dc.subject | immunotherapy | en |
dc.title | Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Stem Cell Reports | en |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1935 | - |
dc.identifier.epage | 1946 | - |
dc.relation.doi | 10.1016/j.stemcr.2018.04.025 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 29805109 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2018-06-04 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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