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Title: Thermo-reversible supramolecular hydrogels of trehalose-type diblock methylcellulose analogues
Authors: Yamagami, Mao
Kamitakahara, Hiroshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0130-1919 (unconfirmed)
Yoshinaga, Arata  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2935-3067 (unconfirmed)
Takano, Toshiyuki  kyouindb  KAKEN_id
Author's alias: 上髙原, 浩
吉永, 新
髙野, 俊幸
Keywords: Methylcellulose
Polysaccharides
Diblock copolymer
End-functionalization
Surface activity
Thermo-reversible supramolecular hydrogels
Issue Date: 1-Mar-2018
Publisher: Elsevier Ltd
Journal title: Carbohydrate Polymers
Volume: 183
Start page: 110
End page: 122
Abstract: This paper describes the design and synthesis of new trehalose-type diblock methylcellulose analogues with nonionic, cationic, and anionic cellobiosyl segments, namely 1-(tri-O-methyl-cellulosyl)-4-[β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyloxymethyl]-1H-1, 2, 3-triazole (1), 1-(tri-O-methyl-cellulosyl)-4-[(6-amino-6-deoxy-β-d-glucopyranosyl)-(1 → 4)- 6-amino-6-deoxy-β-d-glucopyranosyloxymethyl]-1H-1, 2, 3-triazole (2), and 4-(tri-O-methyl-cellulosyloxymethyl)-1-[β-d-glucopyranuronosyl-(1 → 4)-β-d-glucopyranuronosyl]-1H-1, 2, 3-triazole (3), respectively. Aqueous solutions of all of the 1, 2, 3-triazole-linked diblock methylcellulose analogues possessed higher surface activities than that of industrially produced methylcellulose and exhibited lower critical solution temperatures, that allowed the formation of thermoresponsive supramolecular hydrogels at close to human body temperature. Supramolecular structures of thermo-reversible hydrogels based on compounds 1, 2, and 3 were investigated by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Detailed structure-property-function relationships of compounds 1, 2, and 3 were discussed. Not only nonionic hydrophilic segment but also ionic hydrophilic segments of diblock methylcellulose analogues were valid for the formation of thermo-reversible supramolecular hydrogels based on end-functionalized methylcellulose.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 March 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/231416
DOI(Published Version): 10.1016/j.carbpol.2017.12.006
PubMed ID: 29352866
Appears in Collections:Journal Articles

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