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Title: | Thermo-reversible supramolecular hydrogels of trehalose-type diblock methylcellulose analogues |
Authors: | Yamagami, Mao Kamitakahara, Hiroshi ![]() ![]() ![]() Yoshinaga, Arata ![]() ![]() ![]() Takano, Toshiyuki ![]() ![]() |
Author's alias: | 上髙原, 浩 吉永, 新 髙野, 俊幸 |
Keywords: | Methylcellulose Polysaccharides Diblock copolymer End-functionalization Surface activity Thermo-reversible supramolecular hydrogels |
Issue Date: | 1-Mar-2018 |
Publisher: | Elsevier Ltd |
Journal title: | Carbohydrate Polymers |
Volume: | 183 |
Start page: | 110 |
End page: | 122 |
Abstract: | This paper describes the design and synthesis of new trehalose-type diblock methylcellulose analogues with nonionic, cationic, and anionic cellobiosyl segments, namely 1-(tri-O-methyl-cellulosyl)-4-[β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyloxymethyl]-1H-1, 2, 3-triazole (1), 1-(tri-O-methyl-cellulosyl)-4-[(6-amino-6-deoxy-β-d-glucopyranosyl)-(1 → 4)- 6-amino-6-deoxy-β-d-glucopyranosyloxymethyl]-1H-1, 2, 3-triazole (2), and 4-(tri-O-methyl-cellulosyloxymethyl)-1-[β-d-glucopyranuronosyl-(1 → 4)-β-d-glucopyranuronosyl]-1H-1, 2, 3-triazole (3), respectively. Aqueous solutions of all of the 1, 2, 3-triazole-linked diblock methylcellulose analogues possessed higher surface activities than that of industrially produced methylcellulose and exhibited lower critical solution temperatures, that allowed the formation of thermoresponsive supramolecular hydrogels at close to human body temperature. Supramolecular structures of thermo-reversible hydrogels based on compounds 1, 2, and 3 were investigated by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Detailed structure-property-function relationships of compounds 1, 2, and 3 were discussed. Not only nonionic hydrophilic segment but also ionic hydrophilic segments of diblock methylcellulose analogues were valid for the formation of thermo-reversible supramolecular hydrogels based on end-functionalized methylcellulose. |
Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 March 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/231416 |
DOI(Published Version): | 10.1016/j.carbpol.2017.12.006 |
PubMed ID: | 29352866 |
Appears in Collections: | Journal Articles |

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