ダウンロード数: 314
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.bbrc.2018.04.020.pdf | 2.64 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Hamaoka, Yuho | en |
dc.contributor.author | Negishi, Manabu | en |
dc.contributor.author | Katoh, Hironori | en |
dc.contributor.alternative | 根岸, 学 | ja |
dc.contributor.alternative | 加藤, 裕教 | ja |
dc.date.accessioned | 2018-06-11T08:04:47Z | - |
dc.date.available | 2018-06-11T08:04:47Z | - |
dc.date.issued | 2018-05-23 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/2433/231897 | - |
dc.description.abstract | EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported to promote tumor malignancy through phosphorylation of serine 897 (S897). Here, we found that overexpression of wild-type EphA2 induced S897 phosphorylation through ERK activation without growth factors or cytokines and promoted glioblastoma cell proliferation. However, overexpression of a kinase-inactive mutant of EphA2 failed to induce ERK activation, S897 phosphorylation, and promotion of glioblastoma cell proliferation. These data suggest that when overexpressed, EphA2 induces ERK activation through its tyrosine kinase activity, leading to S897 phosphorylation and promotion of glioblastoma cell proliferation. Our findings provide a new insight into how EphA2 mediates glioblastoma progression. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 23 May 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | EphA2 | en |
dc.subject | ERK | en |
dc.subject | Cell proliferation | en |
dc.subject | Glioblastoma | en |
dc.title | Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00564395 | - |
dc.identifier.jtitle | Biochemical and Biophysical Research Communications | en |
dc.identifier.volume | 499 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 920 | - |
dc.identifier.epage | 926 | - |
dc.relation.doi | 10.1016/j.bbrc.2018.04.020 | - |
dc.textversion | author | - |
dc.address | Laboratory of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Laboratory of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University・Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University | en |
dc.address | Laboratory of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University・Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University | en |
dc.identifier.pmid | 29626472 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2019-05-23 | - |
datacite.awardNumber | 15K07043 | - |
dc.identifier.pissn | 0006-291X | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。