ダウンロード数: 131
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
dev.163915.pdf | 4.6 MB | Adobe PDF | 見る/開く |
タイトル: | Distinct regulation ofSnailin two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development |
著者: | Tokuoka, Miki Kobayashi, Kenji Satou, Yutaka https://orcid.org/0000-0001-5193-0708 (unconfirmed) |
著者名の別形: | 徳岡, 三紀 小林, 健司 佐藤, ゆたか |
キーワード: | Ascidian Ciona Snail Germline Raf |
発行日: | 6-Jun-2018 |
出版者: | Company of Biologists |
誌名: | Development |
巻: | 145 |
論文番号: | dev163915 |
抄録: | The transcriptional repressor Snail is required for proper differentiation of the tail muscle of ascidian tadpole larvae. Two muscle lineages (B5.1 and B6.4) contribute to the anterior tail muscle cells, and are consecutively separated from a transcriptionally quiescent germ cell lineage at the 16- and 32-cell stages. Concomitantly, cells of these lineages begin to express Tbx6.b (Tbx6-r.b) at the 16- and 32-cell stages, respectively. Meanwhile, Snail expression begins in these two lineages simultaneously at the 32-cell stage. Here, we show that Snail expression is regulated differently between these two lineages. In the B5.1 lineage, Snail was activated through Tbx6.b, which is activated by maternal factors, including Zic-r.a. In the B6.4 lineage, the MAPK pathway was cell-autonomously activated by a constitutively active form of Raf, enabling Zic-r.a to activate Snail independently of Tbx6.b. As a result, Snail begins to be expressed at the 32-cell stage simultaneously in these two lineages. Such shortcuts might be required for coordinating developmental programs in embryos in which cells become separated progressively from stem cells, including germline cells. |
著作権等: | © 2018. Published by The Company of Biologists Ltd. The full-text file will be made open to the public on 6 June 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. |
URI: | http://hdl.handle.net/2433/232531 |
DOI(出版社版): | 10.1242/dev.163915 |
PubMed ID: | 29764858 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。