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Title: Adaptation and conservation insights from the koala genome
Authors: Johnson, Rebecca N.
O’Meally, Denis
Chen, Zhiliang
Etherington, Graham J.
Ho, Simon Y. W.
Nash, Will J.
Grueber, Catherine E.
Cheng, Yuanyuan
Whittington, Camilla M.
Dennison, Siobhan
Peel, Emma
Haerty, Wilfried
O’Neill, Rachel J.
Colgan, Don
Russell, Tonia L.
Alquezar-Planas, David E.
Attenbrow, Val
Bragg, Jason G.
Brandies, Parice A.
Chong, Amanda Yoon-Yee
Deakin, Janine E.
Di Palma, Federica
Duda, Zachary
Eldridge, Mark D. B.
Ewart, Kyle M.
Hogg, Carolyn J.
Frankham, Greta J.
Georges, Arthur
Gillett, Amber K.
Govendir, Merran
Greenwood, Alex D.
Hayakawa, Takashi  kyouindb  KAKEN_id
Helgen, Kristofer M.
Hobbs, Matthew
Holleley, Clare E.
Heider, Thomas N.
Jones, Elizabeth A.
King, Andrew
Madden, Danielle
Graves, Jennifer A. Marshall
Morris, Katrina M.
Neaves, Linda E.
Patel, Hardip R.
Polkinghorne, Adam
Renfree, Marilyn B.
Robin, Charles
Salinas, Ryan
Tsangaras, Kyriakos
Waters, Paul D.
Waters, Shafagh A.
Wright, Belinda
Wilkins, Marc R.
Timms, Peter
Belov, Katherine
Author's alias: 早川, 卓志
Keywords: Genomics
Immunogenetics
Population genetics
Zoology
Issue Date: Aug-2018
Publisher: Springer Nature
Journal title: Nature Genetics
Volume: 50
Issue: 8
Start page: 1102
End page: 1111
Abstract: The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild.
Description: コアラの全ゲノム配列の解読に成功 --コアラはなぜ猛毒のユーカリを食べるのか?--. 京都大学プレスリリース. 2018-07-04.
Rights: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/232590
DOI(Published Version): 10.1038/s41588-018-0153-5
PubMed ID: 29967444
Related Link: http://www.kyoto-u.ac.jp/ja/research/research_results/2018/180703_1.html
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