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dc.contributor.authorKitada, Yusuke
dc.contributor.authorMuramatsu, Koji
dc.contributor.authorToju, Hirokazu
dc.contributor.authorKibe, Ryoko
dc.contributor.authorBenno, Yoshimi
dc.contributor.authorKurihara, Shin
dc.contributor.authorMatsumoto, Mitsuharu
dc.contributor.alternative北田, 雄祐
dc.contributor.alternative村松, 幸治
dc.contributor.alternative東樹, 宏和
dc.contributor.alternative木邊, 量子
dc.contributor.alternative辨野, 義己
dc.contributor.alternative栗原, 新
dc.contributor.alternative松本, 光晴
dc.date.accessioned2018-07-06T05:21:12Z-
dc.date.available2018-07-06T05:21:12Z-
dc.date.issued2018-06-27
dc.identifier.issn2375-2548
dc.identifier.urihttp://hdl.handle.net/2433/232610-
dc.description個々の腸内細菌の生き残り戦略が組み合わさることで、 機能性物質ポリアミンが産生されていることを発見しました. 京都大学プレスリリース. 2018-07-06.
dc.description.abstractMetabolites of the intestinal microbiota are thought to be generated through metabolic pathways spanning multiple taxa of intestinal bacteria. We have previously shown that the level of putrescine, a polyamine found abundantly in the human intestinal lumen, is increased in the colonic lumen following administration of arginine and the probiotic Bifidobacterium sp.; however, the underlying mechanism remained poorly understood. We report a novel pathway for putrescine production from arginine through agmatine involving the collaboration of two bacterial groups, and triggered by environmental acidification (drop in pH to below 6.5 from neutral). This pathway comprises the acid tolerance system of Escherichia coli, representing bacteria that have an arginine-dependent acid resistance system; the energy production system of Enterococcus faecalis, representing bacteria that have an agmatine deiminase system; and the acid production system of the acid-producing bacteria, represented by Bifidobacterium spp. This pathway is unique in that it represents a relationship between the independent survival strategies of multiple bacteria.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rights© 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
dc.titleBioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies
dc.type.niitypeJournal Article
dc.identifier.jtitleScience Advances
dc.identifier.volume4
dc.identifier.issue6
dc.relation.doi10.1126/sciadv.aat0062
dc.textversionpublisher
dc.identifier.artnumeaat0062
dc.identifier.pmid29963630
dc.relation.urlhttp://www.kyoto-u.ac.jp/ja/research/research_results/2018/180628_1.html
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