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タイトル: | Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat |
著者: | Ohara, Shinya Onodera, Mariko Simonsen, Øyvind W. Yoshino, Rintaro Hioki, Hiroyuki Iijima, Toshio Tsutsui, Ken-Ichiro Witter, Menno P. |
著者名の別形: | 日置, 寛之 |
キーワード: | parahippocampus rodent interlaminar connectivity hippocampal-entorhinal connections hippocampal-cortical connections |
発行日: | 3-Jul-2018 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 24 |
号: | 1 |
開始ページ: | 107 |
終了ページ: | 116 |
抄録: | Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal projections, whereas the superficial-sublayer LVa, immunonegative for Ctip2, originates the main outputs of EC. This disrupts the proposed role of EC as mediating hippocampal-cortical interactions. With the use of specific (trans)synaptic tracing approaches, we report that, in medial entorhinal cortex, layer Vb neurons innervate neurons in layers Va, II, and III. A similar circuitry exists in the lateral entorhinal cortex. We conclude that EC-layer Vb neurons mediate two circuits in the hippocampus-memory system: (1) a hippocampal output circuit to telencephalic areas by projecting to layer Va and (2) a feedback projection, sending information back to the EC-hippocampal loop via neurons in layers II and III. |
著作権等: | © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/232698 |
DOI(出版社版): | 10.1016/j.celrep.2018.06.014 |
PubMed ID: | 29972772 |
出現コレクション: | 学術雑誌掲載論文等 |
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