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Title: Mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of mice with MPTP-induced Parkinson's disease
Authors: Kusuda, Yuina
Takemura, Ai
Nakano, Masaki
Ishihara, Akihiko  kyouindb  KAKEN_id
Author's alias: 石原, 昭彦
Keywords: Balance beam test
Dissolved oxygen
Enhanced atmosphere absolute
Immunohistochemistry
Increased oxygen concentration
Oxidative metabolism
Rotarod test
Issue Date: Jul-2018
Publisher: Elsevier Ireland Ltd
Journal title: Neuroscience Research
Volume: 132
Start page: 58
End page: 62
Abstract: We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of a neurotoxic animal model with Parkinson’s disease. Mice injected with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen were exposed to 1317 hPa with 45% oxygen for 3 h, three times a week. The decrease in dopaminergic neurons of mice with Parkinson’s disease was inhibited by 11 weeks of exposure to mild hyperbaric oxygen. We conclude that exposure to mild hyperbaric oxygen is effective in preventing the progression of Parkinson’s disease.
Rights: © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/232712
DOI(Published Version): 10.1016/j.neures.2017.11.008
PubMed ID: 29196223
Appears in Collections:Journal Articles

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