ダウンロード数: 322
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.neures.2017.11.008.pdf | 1.51 MB | Adobe PDF | 見る/開く |
タイトル: | Mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of mice with MPTP-induced Parkinson's disease |
著者: | Kusuda, Yuina Takemura, Ai Nakano, Masaki Ishihara, Akihiko |
著者名の別形: | 石原, 昭彦 |
キーワード: | Balance beam test Dissolved oxygen Enhanced atmosphere absolute Immunohistochemistry Increased oxygen concentration Oxidative metabolism Rotarod test |
発行日: | Jul-2018 |
出版者: | Elsevier Ireland Ltd |
誌名: | Neuroscience Research |
巻: | 132 |
開始ページ: | 58 |
終了ページ: | 62 |
抄録: | We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of a neurotoxic animal model with Parkinson’s disease. Mice injected with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen were exposed to 1317 hPa with 45% oxygen for 3 h, three times a week. The decrease in dopaminergic neurons of mice with Parkinson’s disease was inhibited by 11 weeks of exposure to mild hyperbaric oxygen. We conclude that exposure to mild hyperbaric oxygen is effective in preventing the progression of Parkinson’s disease. |
著作権等: | © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/232712 |
DOI(出版社版): | 10.1016/j.neures.2017.11.008 |
PubMed ID: | 29196223 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。