Polymeric micelle of a3 b-type lactosome as a vehicle for targeting meningeal dissemination

Abstract

Polymeric micelle of the A₃B-type lactosome comprising (poly(sarcosine))₃-b-poly(l-lactic acid) was labeled with ¹¹¹In. The ¹¹¹In-labeled A₃B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by ¹¹¹In-labeled A₃B-type lactosome, which was superior to ²⁰¹TlCl in regard of the imaging contrast. The ¹¹¹In-labeled A₃B-type lactosome was also potential in imaging selectively of bone metastasis at mandible, whilst a nonspecific imaging of the whole bone was obtained by the SPECT imaging using ⁹⁹mTc-HMDP. The polymeric micelle of the A₃B-type lactosome was therefore found to be effective as a vehicle of ¹¹¹In to be targeted to meningeal dissemination and bone metastasis.