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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41598-018-29700-3.pdf | 6.76 MB | Adobe PDF | 見る/開く |
| タイトル: | Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells |
| 著者: | Kuroda, Mito    https://orcid.org/0000-0001-7752-3334 (unconfirmed)Ueda, Kazumitsu https://orcid.org/0000-0003-2980-6078 (unconfirmed)Kioka, Noriyuki https://orcid.org/0000-0002-2708-537X (unconfirmed) |
| 著者名の別形: | 黒田, 美都 植田, 和光 木岡, 紀幸 |
| 発行日: | 1-Aug-2018 |
| 出版者: | Nature Publishing Group |
| 誌名: | Scientific Reports |
| 巻: | 8 |
| 論文番号: | 11581 |
| 抄録: | The stiffness of extracellular matrix (ECM) directs the differentiation of mesenchymal stem cells (MSCs) through the transcriptional co-activators Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ). Although a recent study revealed the involvement of vinexin α and CAP (c-Cbl-associated proteins), two of vinexin (SORBS) family proteins that bind to vinculin, in mechanosensing, it is still unclear whether these proteins regulate mechanotransduction and differentiation of MSCs. In the present study, we show that both vinexin α and CAP are necessary for the association of vinculin with the cytoskeleton and the promotion of YAP/TAZ nuclear localization in MSCs grown on rigid substrates. Furthermore, CAP is involved in the MSC differentiation in a stiffness-dependent manner, whereas vinexin depletion suppresses adipocyte differentiation independently of YAP/TAZ. These observations reveal a critical role of vinexin α and CAP in mechanotransduction and MSC differentiation. |
| 著作権等: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/233968 |
| DOI(出版社版): | 10.1038/s41598-018-29700-3 |
| PubMed ID: | 30068914 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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