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dc.contributor.author | Hamada, Miho | en |
dc.contributor.author | Matsukawa, Shino | en |
dc.contributor.author | Shimizu, Satoshi | en |
dc.contributor.author | Kai, Shinichi | en |
dc.contributor.author | Mizota, Toshiyuki | en |
dc.contributor.alternative | 松川, 志乃 | ja |
dc.contributor.alternative | 清水, 覚司 | ja |
dc.contributor.alternative | 甲斐, 慎一 | ja |
dc.contributor.alternative | 溝田, 敏幸 | ja |
dc.date.accessioned | 2018-09-03T00:53:00Z | - |
dc.date.available | 2018-09-03T00:53:00Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0913-8668 | - |
dc.identifier.uri | http://hdl.handle.net/2433/234193 | - |
dc.description.abstract | [Purpose]: Data on the incidence of, risk factors for, and association with outcomes of acute kidney injury (AKI) after pediatric liver transplantation are scarce. We conducted a retrospective cohort study to determine the incidence of AKI after pediatric liver transplantation. In addition, we examined risk factors for AKI and association of AKI with outcomes. [Methods]: This study included 156 children aged between 3 months and 18 years undergoing liver transplantation at Kyoto University Hospital. AKI was defined according to the Kidney Disease: Improving Global Outcomes guidelines based on serum creatinine and urine output. We used multivariable logistic regression with stepwise variable selection to identify independent risk factors for AKI. [Results]: AKI occurred in 72 patients (46.2%); 34 (21.8%) had stage 1, 32 (20.5%) had stage 2, and 6 (3.8%) had stage 3 AKI. Factors independently associated with the development of AKI were increased preoperative total bilirubin level (adjusted odds ratio, 1.04 per 1 mg/dl; 95% confidence interval, 1.01–1.09; P = 0.026) and increased intraoperative blood loss (adjusted odds ratio, 1.03 per 10 ml/kg; 95% confidence interval, 1.00–1.06; P = 0.022). AKI was significantly associated with prolonged hospitalization (median, 61 vs. 46 days; P = 0.028). In-hospital mortality rate was 4.2% in patients with AKI and 3.6% in those without AKI (P = 1.000). [Conclusion]: The incidence of AKI after pediatric liver transplantation was 46.2%. Increased preoperative total bilirubin level and increased intraoperative blood loss were independently associated with the development of AKI. AKI was associated with prolonged hospitalization. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in Journal of Anesthesia. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00540-017-2395-2. | en |
dc.rights | The full-text file will be made open to the public on 01 August 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Acute kidney injury | en |
dc.subject | Adolescent | en |
dc.subject | Child | en |
dc.subject | Infant | en |
dc.subject | Liver transplantation | en |
dc.title | Acute kidney injury after pediatric liver transplantation: incidence, risk factors, and association with outcome | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10852931 | - |
dc.identifier.jtitle | Journal of Anesthesia | en |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 758 | - |
dc.identifier.epage | 763 | - |
dc.relation.doi | 10.1007/s00540-017-2395-2 | - |
dc.textversion | author | - |
dc.address | Department of AnesthesiaKyoto University Hospital | en |
dc.address | Department of AnesthesiaKyoto University Hospital | en |
dc.address | Department of AnesthesiaKyoto University Hospital | en |
dc.address | Department of AnesthesiaKyoto University Hospital | en |
dc.address | Department of AnesthesiaKyoto University Hospital | en |
dc.identifier.pmid | 28766021 | - |
dc.relation.NAID | 40021346918 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 16K20092 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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