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Title: AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement
Authors: Ikawa, Keisuke
Sugimura, Kaoru  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 井川, 敬介
杉村, 薫
Keywords: Cytoskeleton
Issue Date: 10-Sep-2018
Publisher: Springer Nature America, Inc
Journal title: Nature Communications
Volume: 9
Thesis number: 3295
Abstract: In order to understand how tissue mechanics shapes animal body, it is critical to clarify how cells respond to and resist tissue stress when undergoing morphogenetic processes, such as cell rearrangement. Here, we address the question in the Drosophila wing epithelium, where anisotropic tissue tension orients cell rearrangements. We found that anisotropic tissue tension localizes actin interacting protein 1 (AIP1), a cofactor of cofilin, on the remodeling junction via cooperative binding of cofilin to F-actin. AIP1 and cofilin promote actin turnover and locally regulate the Canoe-mediated linkage between actomyosin and the junction. This mechanism is essential for cells to resist the mechanical load imposed on the remodeling junction perpendicular to the direction of tissue stretching. Thus, the present study delineates how AIP1 and cofilin achieve an optimal balance between resistance to tissue tension and morphogenesis.
Description: 個体発生過程における新しい力感知・力抵抗メカニズムを発見しました. 京都大学プレスリリース. 2018-09-10.
Rights: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI(Published Version): 10.1038/s41467-018-05605-7
PubMed ID: 30202062
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