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タイトル: | Long-term efficacy and safety of anti-VEGF therapy in retinitis pigmentosa: a case report |
著者: | Miyata, Manabu https://orcid.org/0000-0002-7574-1749 (unconfirmed) Oishi, Akio Oishi, Maho Hasegawa, Tomoko Ohashi Ikeda, Hanako Tsujikawa, Akitaka |
著者名の別形: | 宮田, 学 大石, 明生 大石, 真秀 長谷川, 智子 池田, 華子 辻川, 明孝 |
キーワード: | Retinitis pigmentosa Anti-VEGF therapy Choroidal neovascularization Long-term PRPH2 |
発行日: | 14-Sep-2018 |
出版者: | BMC |
誌名: | BMC ophthalmology |
巻: | 18 |
論文番号: | 248 |
抄録: | [Background]Retinitis pigmentosa (RP), a neurodegenerative disease, is occasionally accompanied by choroidal neovascularization (CNV) and cystoid macular oedema. It is presently treated with repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. However, there are concerns regarding long-term inhibition of VEGF by the use of these agents, especially in cases involving neurodegenerative diseases, since VEGFs have a neuroprotective effect. Currently, there are no reports on the long-term safety of anti-VEGF therapy in patients with RP. [Case presentation]In this report, we describe the case of a 56-year-old female patient with CNV associated with RP who was treated with anti-VEGF therapy for 8 years. She had autosomal dominant RP with a heterozygous PRPH2 mutation (c.410G > A) and complained of metamorphopsia in her left eye. Examinations revealed CNV with serous retinal detachment. She was treated with as-needed injections for 2 years; however, she experienced a recurrence. Therefore, we switched to a bimonthly regimen that was continued for 6 years. In total, the patient received 34 injections of various types of anti-VEGFs over 8 years. No recurrences were noted during that time, and we have not detected any negative effects concerning the progression of visual field loss in comparison with the fellow eye. [Conclusions]No negative effects related to the progression of visual field loss were observed during continuous treatment with anti-VEGF agents for 8 years in our patient. |
著作権等: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
URI: | http://hdl.handle.net/2433/234583 |
DOI(出版社版): | 10.1186/s12886-018-0914-z |
PubMed ID: | 30217183 |
出現コレクション: | 学術雑誌掲載論文等 |
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