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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41598-018-21582-9.pdf | 1.31 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Kato, Fumihiro | en |
| dc.contributor.author | Ishida, Yuki | en |
| dc.contributor.author | Kawakami, Akihiko | en |
| dc.contributor.author | Takasaki, Tomohiko | en |
| dc.contributor.author | Saijo, Masayuki | en |
| dc.contributor.author | Miura, Tomoyuki | en |
| dc.contributor.author | Hishiki, Takayuki | en |
| dc.contributor.alternative | 加藤, 文博 | ja |
| dc.contributor.alternative | 三浦, 智行 | ja |
| dc.contributor.alternative | 日紫喜, 隆行 | ja |
| dc.date.accessioned | 2018-09-25T05:53:39Z | - |
| dc.date.available | 2018-09-25T05:53:39Z | - |
| dc.date.issued | 2018-02-21 | - |
| dc.identifier.issn | 2045-2322 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/234604 | - |
| dc.description.abstract | Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Springer Nature | en |
| dc.rights | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
| dc.title | Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.jtitle | Scientific Reports | en |
| dc.identifier.volume | 8 | - |
| dc.relation.doi | 10.1038/s41598-018-21582-9 | - |
| dc.textversion | publisher | - |
| dc.identifier.artnum | 3421 | - |
| dc.address | Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University・Department of Virology 1, National Institute of Infectious Diseases, Tokyo | en |
| dc.address | Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University | en |
| dc.address | Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University | en |
| dc.address | Department of Virology 1, National Institute of Infectious Diseases, Tokyo・Kanagawa Prefectural Institute of Public Health | en |
| dc.address | Department of Virology 1, National Institute of Infectious Diseases, Tokyo | en |
| dc.address | Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University | en |
| dc.address | Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University・Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science | en |
| dc.identifier.pmid | 29467430 | - |
| dcterms.accessRights | open access | - |
| datacite.awardNumber | JP15K19109 | - |
| datacite.awardNumber | JP17K08870 | - |
| jpcoar.funderName | 日本学術振興会 | ja |
| jpcoar.funderName | 日本学術振興会 | ja |
| jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
| jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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