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タイトル: 当院における転移性腎細胞癌に対するアキシチニブの治療成績
その他のタイトル: Treatment Outcome of Axitinib for Metastatic Renal-Cell Carcinoma Patients
著者: 日下部, 直久  KAKEN_name
大澤, 崇宏  KAKEN_name
宮田, 遥  KAKEN_name
菊地, 央  KAKEN_name
松本, 隆児  KAKEN_name
丸山, 覚  KAKEN_name
安部, 崇重  KAKEN_name
篠原, 信雄  KAKEN_name
著者名の別形: Kusakabe, Naohisa
Osawa, Takahiro
Miyata, Haruka
Kikuchi, Hiroshi
Matsumoto, Ryuji
Maruyama, Satoru
Abe, Takashige
Shinohara, Nobuo
キーワード: Renal-cell carcinoma
Axitinib
Metastasis
Targeted therapy
発行日: 30-Sep-2018
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要 = Acta urologica Japonica
巻: 64
号: 9
開始ページ: 353
終了ページ: 358
抄録: Axitinib was approved for use in Japan as a salvage therapy for patients with metastatic renal cell carcinoma (RCC) in 2012. We retrospectively evaluated the cases of 32 RCC patients that were treated with Axitinib as a 2nd- or further-line therapy between November 2012 and March 2017. Overall survival (OS), progression-free survival (PFS), and adverse events were assessed. The median OS and PFS from the initiation of Axitinib were 29 and 11 months, respectively. Nineteen patients received Axitinib as a 2nd-line treatment, in whom the median OS and median PFS were 22 and 10 months, respectively, while the median OS and PFS were 29 and 15.5 months, respectively, amongthe 13 patients who received Axitinib as a 3rd- or further-line treatment, which suggested that Axitinib is effective in the 3rd-line and further-line settings. A Cox multivariate model revealed that bone metastasis was a significant adverse factor for OS. Common grade 3 or higher adverse events included hypertension (28%), diarrhea (7%), and proteinuria (7%). Although the present study demonstrated the efficacy and safety of salvage Axitinib treatment in patients who had recurrent disease after the initial systemic therapy, further large-scale studies should be warranted to make clear its clinical effectiveness in these patients.
著作権等: 許諾条件により本文は2019/10/01に公開
DOI: 10.14989/ActaUrolJap_64_9_353
URI: http://hdl.handle.net/2433/234832
PubMed ID: 30369225
出現コレクション:Vol.64 No.9

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