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dc.contributor.author | Satow, Takeshi | en |
dc.contributor.author | Aso, Toshihiko | en |
dc.contributor.author | Nishida, Sei | en |
dc.contributor.author | Komuro, Taro | en |
dc.contributor.author | Ueno, Tsukasa | en |
dc.contributor.author | Oishi, Naoya | en |
dc.contributor.author | Nakagami, Yukako | en |
dc.contributor.author | Odagiri, Masashi | en |
dc.contributor.author | Kikuchi, Takayuki | en |
dc.contributor.author | Yoshida, Kazumichi | en |
dc.contributor.author | Ueda, Keita | en |
dc.contributor.author | Kunieda, Takeharu | en |
dc.contributor.author | Murai, Toshiya | en |
dc.contributor.author | Miyamoto, Susumu | en |
dc.contributor.author | Fukuyama, Hidenao | en |
dc.contributor.alternative | 麻生, 俊彦 | ja |
dc.contributor.alternative | 西田, 誠 | ja |
dc.contributor.alternative | 植野, 司 | ja |
dc.contributor.alternative | 大石, 直也 | ja |
dc.contributor.alternative | 中神, 由香子 | ja |
dc.contributor.alternative | 菊池, 隆幸 | ja |
dc.contributor.alternative | 吉田, 和道 | ja |
dc.contributor.alternative | 上田, 敬太 | ja |
dc.contributor.alternative | 國枝, 武治 | ja |
dc.contributor.alternative | 村井, 俊哉 | ja |
dc.contributor.alternative | 宮本, 享 | ja |
dc.contributor.alternative | 福山, 秀直 | ja |
dc.date.accessioned | 2018-10-30T05:22:02Z | - |
dc.date.available | 2018-10-30T05:22:02Z | - |
dc.date.issued | 2017-11-23 | - |
dc.identifier.issn | 1663-4365 | - |
dc.identifier.uri | http://hdl.handle.net/2433/234847 | - |
dc.description.abstract | Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar “tap test” on the cerebral circulation in patients with iNPH, 14 patients with “probable” iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | en |
dc.rights | © 2017 Satow, Aso, Nishida, Komuro, Ueno, Oishi, Nakagami, Odagiri, Kikuchi, Yoshida, Ueda, Kunieda, Murai, Miyamoto and Fukuyama. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en |
dc.subject | normal pressure hydrocephalus | en |
dc.subject | cerebral venous drainage | en |
dc.subject | normal aging | en |
dc.subject | BOLD signal | en |
dc.subject | low-frequency oscillation in systemic circulation | en |
dc.subject | cerebral blood flow | en |
dc.title | Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Frontiers in Aging Neuroscience | en |
dc.identifier.volume | 9 | - |
dc.relation.doi | 10.3389/fnagi.2017.00387 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 387 | - |
dc.identifier.pmid | 29218007 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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