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dc.contributor.author | Egawa, Tatsuro | en |
dc.contributor.author | Ohno, Yoshitaka | en |
dc.contributor.author | Goto, Ayumi | en |
dc.contributor.author | Yokoyama, Shingo | en |
dc.contributor.author | Hayashi, Tatsuya | en |
dc.contributor.author | Goto, Katsumasa | en |
dc.contributor.alternative | 江川, 達郎 | ja |
dc.contributor.alternative | 後藤, 亜由美 | ja |
dc.contributor.alternative | 林, 達也 | ja |
dc.date.accessioned | 2018-11-02T01:21:14Z | - |
dc.date.available | 2018-11-02T01:21:14Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/2433/234927 | - |
dc.description.abstract | 5′AMP-activated protein kinase (AMPK) plays an important role in the regulation of skeletal muscle mass and fiber-type distribution. However, it is unclear whether AMPK is involved in muscle mass change or transition of myosin heavy chain (MyHC) isoforms in response to unloading or increased loading. Here, we checked whether AMPK controls muscle mass change and transition of MyHC isoforms during unloading and reloading using mice expressing a skeletal-muscle-specific dominant-negative AMPKα1 (AMPK-DN). Fourteen days of hindlimb unloading reduced the soleus muscle weight in wild-type and AMPK-DN mice, but reduction in the muscle mass was partly attenuated in AMPK-DN mice. There was no difference in the regrown muscle weight between the mice after 7 days of reloading, and there was concomitantly reduced AMPKα2 activity, however it was higher in AMPK-DN mice after 14 days reloading. No difference was observed between the mice in relation to the levels of slow-type MyHC I, fast-type MyHC IIa/x, and MyHC IIb isoforms following unloading and reloading. The levels of 72-kDa heat-shock protein, which preserves muscle mass, increased in AMPK-DN-mice. Our results indicate that AMPK mediates the progress of atrophy during unloading and regrowth of atrophied muscles following reloading, but it does not influence the transition of MyHC isoforms. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | en |
dc.rights | © 2018 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | en |
dc.subject | atrophy | en |
dc.subject | regrowth | en |
dc.subject | sirtuin 1 (SIRT1) | en |
dc.subject | peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α) | en |
dc.subject | heat shock protein | en |
dc.subject | fiber-type | en |
dc.title | AMPK Mediates Muscle Mass Change But Not the Transition of Myosin Heavy Chain Isoforms during Unloading and Reloading of Skeletal Muscles in Mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | International Journal of Molecular Sciences | en |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 10 | - |
dc.relation.doi | 10.3390/ijms19102954 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 2954 | - |
dc.address | Department of Physiology, Graduate School of Health Sciences, Toyohashi SOZO University・Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University・Laboratory of Health and Exercise Sciences, Graduate School of Human and Environmental Studies, Kyoto University | en |
dc.address | Laboratory of Physiology, School of Health Sciences, Toyohashi SOZO University | en |
dc.address | Department of Physiology, Graduate School of Health Sciences, Toyohashi SOZO University・Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University | en |
dc.address | Laboratory of Physiology, School of Health Sciences, Toyohashi SOZO University | en |
dc.address | Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University | en |
dc.address | Department of Physiology, Graduate School of Health Sciences, Toyohashi SOZO University・Laboratory of Physiology, School of Health Sciences, Toyohashi SOZO University | en |
dc.identifier.pmid | 30262782 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 26560371 | - |
datacite.awardNumber | 18H03148 | - |
datacite.awardNumber | 16K12942 | - |
datacite.awardNumber | 18K10796 | - |
datacite.awardNumber | 16H07182 | - |
datacite.awardNumber | 18K17934 | - |
datacite.awardNumber | 16K16450 | - |
datacite.awardNumber | 16K13022 | - |
datacite.awardNumber | 17K01762 | - |
datacite.awardNumber | 18H03160 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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