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j.celrep.2018.10.008.pdf | 3.57 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Hashimoto, Osamu | en |
dc.contributor.author | Funaba, Masayuki | en |
dc.contributor.author | Sekiyama, Kazunari | en |
dc.contributor.author | Doi, Satoru | en |
dc.contributor.author | Shindo, Daichi | en |
dc.contributor.author | Satoh, Ryo | en |
dc.contributor.author | Itoi, Hiroshi | en |
dc.contributor.author | Oiwa, Hiroaki | en |
dc.contributor.author | Morita, Masahiro | en |
dc.contributor.author | Suzuki, Chisato | en |
dc.contributor.author | Sugiyama, Makoto | en |
dc.contributor.author | Yamakawa, Norio | en |
dc.contributor.author | Takada, Hitomi | en |
dc.contributor.author | Matsumura, Shigenobu | en |
dc.contributor.author | Inoue, Kazuo | en |
dc.contributor.author | Oyadomari, Seiichi | en |
dc.contributor.author | Sugino, Hiromu | en |
dc.contributor.author | Kurisaki, Akira | en |
dc.contributor.alternative | 橋本, 統 | ja |
dc.contributor.alternative | 舟場, 正幸 | ja |
dc.contributor.alternative | 関山, 一成 | ja |
dc.contributor.alternative | 杉山, 真言 | ja |
dc.contributor.alternative | 高田, 仁実 | ja |
dc.contributor.alternative | 松村, 成暢 | ja |
dc.contributor.alternative | 井上, 和生 | ja |
dc.contributor.alternative | 親泊, 政一 | ja |
dc.contributor.alternative | 杉野, 弘 | ja |
dc.contributor.alternative | 栗崎, 晃 | ja |
dc.date.accessioned | 2018-11-05T05:40:11Z | - |
dc.date.available | 2018-11-05T05:40:11Z | - |
dc.date.issued | 2018-10-30 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2433/234944 | - |
dc.description | アクチビンEが脂肪燃焼細胞の増加を促進することを解明 --肥満解消の新たなプレイヤーを発見--. 京都大学プレスリリース. 2018-11-02. | ja |
dc.description.abstract | Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhances thermogenesis in response to cold exposure through beige adipocyte emergence in inguinal WAT (ingWAT). Hepatic activin E overexpression activated thermogenesis through Ucp1 upregulation in ingWAT and other adipose tissues including interscapular brown adipose tissue and mesenteric WAT. Hepatic activin E-transgenic mice exhibited improved insulin sensitivity. Inhibin βE gene silencing inhibited cold-induced Ucp1 induction in ingWAT. Furthermore, in vitro experiments suggested that activin E directly stimulated expression of Ucp1 and Fgf21, which was mediated by transforming growth factor-β or activin type I receptors. We uncovered a function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, suggesting a possible preventive or therapeutic target for obesity. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | activin E | en |
dc.subject | beige adipocyte | en |
dc.subject | brown adipocyte | en |
dc.subject | browning | en |
dc.subject | hepatokine | en |
dc.subject | Inhbe | en |
dc.subject | insulin sensitivity | en |
dc.subject | nonshivering thermogenesis | en |
dc.subject | obesity | en |
dc.title | Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Reports | en |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1193 | - |
dc.identifier.epage | 1203 | - |
dc.relation.doi | 10.1016/j.celrep.2018.10.008 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 30380411 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2018-11-02-1 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 21580370 | - |
datacite.awardNumber | 26450442 | - |
datacite.awardNumber | 25640109 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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