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タイトル: Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter
著者: Shinoda, Tomoyasu
Nagasaka, Arata
Inoue, Yasuhiro  kyouindb  KAKEN_id
Higuchi, Ryo
Minami, Yoshiaki
Kato, Kagayaki
Suzuki, Makoto
Kondo, Takefumi  kyouindb  KAKEN_id
Kawaue, Takumi
Saito, Kanako
Ueno, Naoto
Fukazawa, Yugo
Nagayama, Masaharu
Miura, Takashi
Adachi, Taiji
Miyata, Takaki
著者名の別形: 井上, 康博
近藤, 武史
安達, 泰治
キーワード: General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Agricultural and Biological Sciences
発行日: 20-Apr-2018
出版者: Public Library of Science (PLoS)
誌名: PLOS Biology
巻: 16
号: 4
論文番号: e2004426
抄録: Neural progenitor cells (NPCs), which are apicobasally elongated and densely packed in the developing brain, systematically move their nuclei/somata in a cell cycle–dependent manner, called interkinetic nuclear migration (IKNM): apical during G2 and basal during G1. Although intracellular molecular mechanisms of individual IKNM have been explored, how heterogeneous IKNMs are collectively coordinated is unknown. Our quantitative cell-biological and in silico analyses revealed that tissue elasticity mechanically assists an initial step of basalward IKNM. When the soma of an M-phase progenitor cell rounds up using actomyosin within the subapical space, a microzone within 10 μm from the surface, which is compressed and elastic because of the apical surface’s contractility, laterally pushes the densely neighboring processes of non–M-phase cells. The pressed processes then recoil centripetally and basally to propel the nuclei/somata of the progenitor’s daughter cells. Thus, indirect neighbor-assisted transfer of mechanical energy from mother to daughter helps efficient brain development.
著作権等: © 2018 Shinoda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/235001
DOI(出版社版): 10.1371/journal.pbio.2004426
PubMed ID: 29677184
出現コレクション:学術雑誌掲載論文等

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