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eLife.32222.pdf | 1.28 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Sun, Jiying | en |
dc.contributor.author | Shi, Lin | en |
dc.contributor.author | Kinomura, Aiko | en |
dc.contributor.author | Fukuto, Atsuhiko | en |
dc.contributor.author | Horikoshi, Yasunori | en |
dc.contributor.author | Oma, Yukako | en |
dc.contributor.author | Harata, Masahiko | en |
dc.contributor.author | Ikura, Masae | en |
dc.contributor.author | Ikura, Tsuyoshi | en |
dc.contributor.author | Kanaar, Roland | en |
dc.contributor.author | Tashiro, Satoshi | en |
dc.contributor.alternative | 井倉, 正枝 | ja |
dc.contributor.alternative | 井倉, 毅 | ja |
dc.date.accessioned | 2018-11-16T01:22:19Z | - |
dc.date.available | 2018-11-16T01:22:19Z | - |
dc.date.issued | 2018-05-08 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/2433/235195 | - |
dc.description.abstract | Chromosomal translocations are hallmarks of various types of cancers and leukemias. However, the molecular mechanisms of chromosome translocations remain largely unknown. The ataxia-telangiectasia mutated (ATM) protein, a DNA damage signaling regulator, facilitates DNA repair to prevent chromosome abnormalities. Previously, we showed that ATM deficiency led to the 11q23 chromosome translocation, the most frequent chromosome abnormalities in secondary leukemia. Here, we show that ARP8, a subunit of the INO80 chromatin remodeling complex, is phosphorylated after etoposide treatment. The etoposide-induced phosphorylation of ARP8 is regulated by ATM and ATR, and attenuates its interaction with INO80. The ATM-regulated phosphorylation of ARP8 reduces the excessive loading of INO80 and RAD51 onto the breakpoint cluster region. These findings suggest that the phosphorylation of ARP8, regulated by ATM, plays an important role in maintaining the fidelity of DNA repair to prevent the etoposide-induced 11q23 abnormalities. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences Publications, Ltd | en |
dc.rights | © 2018, Sun et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | en |
dc.title | Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | eLife | en |
dc.identifier.volume | 7 | - |
dc.relation.doi | 10.7554/eLife.32222 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e32222 | - |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University | en |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University | en |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University | en |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University・Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University | en |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University | en |
dc.address | Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University | en |
dc.address | Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University | en |
dc.address | Laboratory of Chromatin Regulatory Network, Department of Mutagenesis, Radiation Biology Center, Kyoto University | en |
dc.address | Laboratory of Chromatin Regulatory Network, Department of Mutagenesis, Radiation Biology Center, Kyoto University | en |
dc.address | Department of Molecular Genetics, Oncode Institute | en |
dc.address | Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University | en |
dc.identifier.pmid | 29759113 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | JP26430114 | - |
datacite.awardNumber | JP16H01312 | - |
datacite.awardNumber | JP15H02821 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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