ダウンロード数: 152
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s41598-018-21353-6.pdf | 1.92 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Lee, Young-A | en |
dc.contributor.author | Obora, Tsukasa | en |
dc.contributor.author | Bondonny, Laura | en |
dc.contributor.author | Toniolo, Amelie | en |
dc.contributor.author | Mivielle, Johanna | en |
dc.contributor.author | Yamaguchi, Yoshie | en |
dc.contributor.author | Kato, Akemi | en |
dc.contributor.author | Takita, Masatoshi | en |
dc.contributor.author | Goto, Yukiori | en |
dc.contributor.alternative | 山口, 佳恵 | ja |
dc.contributor.alternative | 加藤, 朱美 | ja |
dc.contributor.alternative | 後藤, 幸織 | ja |
dc.date.accessioned | 2018-11-16T06:39:25Z | - |
dc.date.available | 2018-11-16T06:39:25Z | - |
dc.date.issued | 2018-02-22 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/235199 | - |
dc.description.abstract | Population density has been suggested to affect social interactions of individuals, but the underlying neural mechanisms remain unclear. In contrast, neurotransmission of monoamines such as serotonin (5-HT) and dopamine (DA) has been demonstrated to play important roles in social behaviors. Here, we investigated whether housing density affected social interactions of rodents and non-human primates housed in groups, and its correlations with monoamines. Japanese macaques exhibited higher plasma 5-HT, but not DA, concentrations than rhesus macaques. Similarly, C57BL/6 mice exhibited higher plasma and brain tissue 5-HT concentrations than DBA2 mice. Under crowding, C57BL/6 mice and Japanese macaques exhibited more prominent social avoidance with mates than DBA2 mice and rhesus macaques, respectively. Although DBA2 mice and rhesus macaques in crowding exhibited elevated plasma stress hormones, such stress hormone elevations associated with crowding were absent in C57BL/6 mice and Japanese macaques. Administration of parachlorophenylalanine, which inhibits 5-HT synthesis, increased social interactions and stress hormones in C57BL/6 mice under crowding. These results suggest that, animals with hyperserotonemia may exhibit social avoidance as an adaptive behavioral strategy to mitigate stress associated with crowding environments, which may also be relevant to psychiatric disorder such as autism spectrum disorder. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.title | The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 8 | - |
dc.relation.doi | 10.1038/s41598-018-21353-6 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 3497 | - |
dc.address | Department of Food Science and Nutrition, Daegu Catholic University | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | École Nationale Vétérinaire de Toulouse | en |
dc.address | École Nationale Vétérinaire de Toulouse | en |
dc.address | École Nationale Vétérinaire de Toulouse | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | Brain Function Measurement Research Group, National Institute of Advanced Industrial Science and Technology, Tsukuba・Brain Science Inspired Life Support Research Center, The University of Electro-Communications, Chofu | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.identifier.pmid | 29472615 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 15K04202 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このリポジトリに保管されているアイテムはすべて著作権により保護されています。