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Title: Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis
Authors: Okuda, S.
Takata, N.
Hasegawa, Y.
Kawada, M.
Inoue, Y.
Adachi, T.
Sasai, Y.
Eiraku, M.
Author's alias: 奥田, 覚
永樂, 元次
Issue Date: 2-Nov-2018
Publisher: American Association for the Advancement of Science (AAAS)
Journal title: Science Advances
Volume: 4
Issue: 11
Thesis number: eaau1354
Abstract: Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D) space, where macroscopic tissue deformations are robustly regulated by multicellular autonomy. It is clear that this robust regulation requires cells to sense and modulate 3D tissue formation across different scales, but its underlying mechanisms are still unclear. To address this question, we developed a versatile computational model of 3D multicellular dynamics at single-cell resolution and combined it with the 3D culture system of pluripotent stem cell–derived optic-cup organoid. The complementary approach enabled quantitative prediction of morphogenesis and its corresponding verification and elucidated that the macroscopic 3D tissue deformation is fed back to individual cellular force generations via mechanosensing. We hereby conclude that mechanical force plays a key role as a feedback regulator to establish the robustness of organogenesis.
Description: 目の丸い形ができる仕組みを解明 --「器官の形作り」の理解から再生医療への貢献に期待--. 京都大学プレスリリース. 2018-11-22.
Rights: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
DOI(Published Version): 10.1126/sciadv.aau1354
PubMed ID: 30474058
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