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dc.contributor.authorNitta, Nao
dc.contributor.authorSugimura, Takeaki
dc.contributor.authorIsozaki, Akihiro
dc.contributor.authorMikami, Hideharu
dc.contributor.authorHiraki, Kei
dc.contributor.authorSakuma, Shinya
dc.contributor.authorIino, Takanori
dc.contributor.authorArai, Fumihito
dc.contributor.authorEndo, Taichiro
dc.contributor.authorFujiwaki, Yasuhiro
dc.contributor.authorFukuzawa, Hideya
dc.contributor.authorHase, Misa
dc.contributor.authorHayakawa, Takeshi
dc.contributor.authorHiramatsu, Kotaro
dc.contributor.authorHoshino, Yu
dc.contributor.authorInaba, Mary
dc.contributor.authorIto, Takuro
dc.contributor.authorKarakawa, Hiroshi
dc.contributor.authorKasai, Yusuke
dc.contributor.authorKoizumi, Kenichi
dc.contributor.authorLee, SangWook
dc.contributor.authorLei, Cheng
dc.contributor.authorLi, Ming
dc.contributor.authorMaeno, Takanori
dc.contributor.authorMatsusaka, Satoshi
dc.contributor.authorMurakami, Daichi
dc.contributor.authorNakagawa, Atsuhiro
dc.contributor.authorOguchi, Yusuke
dc.contributor.authorOikawa, Minoru
dc.contributor.authorOta, Tadataka
dc.contributor.authorShiba, Kiyotaka
dc.contributor.authorShintaku, Hirofumi
dc.contributor.authorShirasaki, Yoshitaka
dc.contributor.authorSuga, Kanako
dc.contributor.authorSuzuki, Yuta
dc.contributor.authorSuzuki, Nobutake
dc.contributor.authorTanaka, Yo
dc.contributor.authorTezuka, Hiroshi
dc.contributor.authorToyokawa, Chihana
dc.contributor.authorYalikun, Yaxiaer
dc.contributor.authorYamada, Makoto
dc.contributor.authorYamagishi, Mai
dc.contributor.authorYamano, Takashi
dc.contributor.authorYasumoto, Atsushi
dc.contributor.authorYatomi, Yutaka
dc.contributor.authorYazawa, Masayuki
dc.contributor.authorDi Carlo, Dino
dc.contributor.authorHosokawa, Yoichiroh
dc.contributor.authorUemura, Sotaro
dc.contributor.authorOzeki, Yasuyuki
dc.contributor.authorGoda, Keisuke
dc.contributor.alternative新田, 尚
dc.contributor.alternative杉村, 武昭
dc.contributor.alternative磯崎, 瑛宏
dc.contributor.alternative三上, 秀治
dc.contributor.alternative平木, 敬
dc.contributor.alternative佐久間, 臣耶
dc.contributor.alternative飯野, 敬矩
dc.contributor.alternative新井, 史人
dc.contributor.alternative遠藤, 太一郎
dc.contributor.alternative藤脇, 康宏
dc.contributor.alternative福澤, 秀哉
dc.contributor.alternative長谷, 美佐
dc.contributor.alternative早川, 健
dc.contributor.alternative平松, 光太郎
dc.contributor.alternative星野, 友
dc.contributor.alternative稲葉, 真理
dc.contributor.alternative伊藤, 卓朗
dc.contributor.alternative唐川, 博
dc.contributor.alternative笠井, 宥佑
dc.contributor.alternative小泉, 賢一
dc.contributor.alternative李, 相旭
dc.contributor.alternative雷, 诚
dc.contributor.alternative前野, 貴則
dc.contributor.alternative松阪, 諭
dc.contributor.alternative中川, 敦寛
dc.contributor.alternative小口, 祐伴
dc.contributor.alternative老川, 稔
dc.contributor.alternative太田, 忠孝
dc.contributor.alternative芝, 清隆
dc.contributor.alternative新宅, 博文
dc.contributor.alternative白崎, 善隆
dc.contributor.alternative菅, 加奈子
dc.contributor.alternative鈴木, 祐太
dc.contributor.alternative鈴木, 信勇
dc.contributor.alternative田中, 陽
dc.contributor.alternative手塚, 宏史
dc.contributor.alternative豊川, 知華
dc.contributor.alternative山田, 誠
dc.contributor.alternative山岸, 舞
dc.contributor.alternative山野, 隆志
dc.contributor.alternative安本, 篤史
dc.contributor.alternative矢冨, 裕
dc.contributor.alternative矢澤, 真幸
dc.contributor.alternative細川, 陽一郎
dc.contributor.alternative上村, 想太郎
dc.contributor.alternative小関, 泰之
dc.contributor.alternative合田, 圭介
dc.date.accessioned2018-12-05T05:54:09Z-
dc.date.available2018-12-05T05:54:09Z-
dc.date.issued2018-09-20
dc.identifier.issn0092-8674
dc.identifier.urihttp://hdl.handle.net/2433/235563-
dc.description世界初のIntelligent Image-Activated Cell Sorterを開発 --細胞画像の深層学習により高速細胞選抜を実現--. 京都大学プレスリリース. 2018-09-05.
dc.description.abstractA fundamental challenge of biology is to understand the vast heterogeneity of cells, particularly how cellular composition, structure, and morphology are linked to cellular physiology. Unfortunately, conventional technologies are limited in uncovering these relations. We present a machine-intelligence technology based on a radically different architecture that realizes real-time image-based intelligent cell sorting at an unprecedented rate. This technology, which we refer to as intelligent image-activated cell sorting, integrates high-throughput cell microscopy, focusing, and sorting on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, decision-making, and actuation. We use it to demonstrate real-time sorting of microalgal and blood cells based on intracellular protein localization and cell-cell interaction from large heterogeneous populations for studying photosynthesis and atherothrombosis, respectively. The technology is highly versatile and expected to enable machine-based scientific discovery in biological, pharmaceutical, and medical sciences.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier BV
dc.rights© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsThe full-text file will be made open to the public on 20 September 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
dc.subjectimage-activated cell sortin
dc.subjectghigh-throughput microscopy
dc.subjecthigh-throughput screening
dc.subjectdeep learning
dc.subjectconvolutional neural network
dc.subjectcellular heterogeneity
dc.subjectmachine intelligence
dc.subjectcellular morphology
dc.titleIntelligent Image-Activated Cell Sorting
dc.type.niitypeJournal Article
dc.identifier.jtitleCell
dc.identifier.volume175
dc.identifier.issue1
dc.identifier.spage266
dc.identifier.epage276.e13
dc.relation.doi10.1016/j.cell.2018.08.028
dc.textversionauthor
dc.identifier.pmid30166209
dc.relation.urlhttp://www.kyoto-u.ac.jp/ja/research/research_results/2018/180828_1.html
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