ダウンロード数: 205
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
fnagi.2018.00358.pdf | 1.47 MB | Adobe PDF | 見る/開く |
タイトル: | Neural correlates of working memory maintenance in advanced aging: Evidence from fMRI |
著者: | Suzuki, Maki Kawagoe, Toshikazu Nishiguchi, Shu Abe, Nobuhito ![]() ![]() ![]() Otsuka, Yuki Nakai, Ryusuke ![]() ![]() ![]() Asano, Kohei Yamada, Minoru Yoshikawa, Sakiko Sekiyama Kaoru |
著者名の別形: | 西口, 周 阿部, 修士 大塚, 結喜 中井, 隆介 浅野, 孝平 山田, 実 吉川, 左紀子 積山, 薫 |
キーワード: | aging fMRI over-recruitment compensation working memory maintenance prefrontal |
発行日: | 6-Nov-2018 |
出版者: | Frontiers Media |
誌名: | Frontiers in Aging Neuroscience |
巻: | 10 |
論文番号: | 358 |
抄録: | Working memory-related brain activity is known to be modulated by aging; particularly, older adults demonstrate greater activity than young adults. However, it is still unclear whether the activity increase in older adults is also observed in advanced aging. The present functional magnetic resonance imaging (fMRI) study was designed to clarify the neural correlates of working memory in advanced aging. Further, we set out to investigate in the case that adults of advanced age do show age-related increase in working memory-related activity, what the functional significance of this over-recruitment might be. Two groups of older adults - “young-old” (61-70 years, n = 17) and “old-old” (77-82 years, n = 16) - were scanned while performing a visual working memory task (the n-back task: 0-back and 1-back). Working memory effects (1-back > 0-back) common to both age groups were identified in several regions, including the bilateral dorsolateral prefrontal cortex (DLPFC), the inferior parietal cortex, and the insula. Greater working memory effects in the old-old than in the young-old group were identified in the right caudal DLPFC. These results were replicated when we performed a separate analysis between two age groups with the same level of working memory performance (the young-old vs. a “high-performing” subset of the old-old group). There were no regions where working memory effects were greater in the young-old group than in the old-old group. Importantly, the magnitude of the over-recruitment working memory effects positively correlated with working memory performance in the old-old group, but not in the young-old group. The present findings suggest that cortical over-recruitment occurs in advanced old age, and that increased activity may serve a compensatory function in mediating working memory performance. |
著作権等: | © 2018 Suzuki, Kawagoe, Nishiguchi, Abe, Otsuka, Nakai, Asano, Yamada, Yoshikawa and Sekiyama. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/235735 |
DOI(出版社版): | 10.3389/fnagi.2018.00358 |
PubMed ID: | 30459595 |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス