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journal.pone.0208985.pdf | 2.33 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Wang, Tianshu | en |
dc.contributor.author | Ito, Akira | en |
dc.contributor.author | Aoyama, Tomoki | en |
dc.contributor.author | Nakahara, Ryo | en |
dc.contributor.author | Nakahata, Akihiro | en |
dc.contributor.author | Ji, Xiang | en |
dc.contributor.author | Zhang, Jue | en |
dc.contributor.author | Kawai, Hideki | en |
dc.contributor.author | Kuroki, Hiroshi | en |
dc.contributor.alternative | 王, 天舒 | ja |
dc.contributor.alternative | 伊藤, 明良 | ja |
dc.contributor.alternative | 青山, 朋樹 | ja |
dc.contributor.alternative | 中原, 崚 | ja |
dc.contributor.alternative | 中畑, 晶博 | ja |
dc.contributor.alternative | 季, 翔 | ja |
dc.contributor.alternative | 張, ジュエ | ja |
dc.contributor.alternative | 河合, 秀紀 | ja |
dc.contributor.alternative | 黒木, 裕士 | ja |
dc.date.accessioned | 2018-12-25T08:00:53Z | - |
dc.date.available | 2018-12-25T08:00:53Z | - |
dc.date.issued | 2018-12-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/235759 | - |
dc.description.abstract | Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Studies utilizing the toe angle for functional evaluation are scarce, and changes in the toe angle following surgery remain unknown. The present study assessed correlations of ankle angle, toe angle and SFI with histomorphometric data, aiming to determine which parameters most accurately reflect changes in histomorphometric data over time. Six Lewis rats were designated as the control group. 30 animals received surgery, six of them were randomly selected on the first, second, third, fourth, and sixth week after surgery for measurements of ankle and toe angles in the “toe-off” phase, and for evaluation of SFI. Histomorphometric analysis were also performed, to determine the number of myelinated nerve fibers, diameters of myelinated nerve fibers, axon diameters, and myelin sheath thicknesses. Furthermore, we investigated changes in ankle angle, toe angle, SFI, and histomorphometric data over time, as well as correlations between ankle angle, toe angle, and SFI with histomorphometric data. The results revealed that changes in SFI, ankle angle, and toe angle highly correlate with histomorphometric data in the rat sciatic nerve crush injury model. Toe angle reflected changes in histomorphometric data with time more precisely than ankle angle or SFI did, and ankle angle was a better prognostic parameter than SFI. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | en |
dc.rights | © 2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PLOS ONE | en |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 12 | - |
dc.relation.doi | 10.1371/journal.pone.0208985 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e0208985 | - |
dc.address | Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.address | Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University | en |
dc.identifier.pmid | 30540822 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 17K13052 | - |
datacite.awardNumber | 26282154 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K13052/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26282154/ | - |
dc.identifier.eissn | 1932-6203 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 低出力超音波パルスによる末梢神経再生の促進をめざす新しい理学療法の検討 | ja |
jpcoar.awardTitle | 再生医療の第四の要素としての再生リハビリテーションの開発 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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