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Title: Conserved fungal effector suppresses PAMP-triggered immunity by targeting plant immune kinases
Authors: Irieda, Hiroki
Inoue, Yoshihiro
Mori, Masashi
Yamada, Kohji
Oshikawa, Yuu
Saitoh, Hiromasa
Uemura, Aiko
Terauchi, Ryohei  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0095-4651 (unconfirmed)
Kitakura, Saeko
Kosaka, Ayumi
Singkaravanit-Ogawa, Suthitar
Takano, Yoshitaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1427-1322 (unconfirmed)
Author's alias: 入枝, 泰樹
井上, 喜博
森, 正之
山田, 晃嗣
齋藤, 宏昌
寺内, 良平
幸坂, 歩
小川, スティター
髙野, 義孝
Keywords: BAK1
BIK1
core effector
PAMP-triggered immunity
phytopathogenic fungi
Issue Date: 8-Jan-2019
Publisher: National Academy of Sciences
Journal title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 116
Issue: 2
Start page: 496
End page: 505
Abstract: Plant pathogens have optimized their own effector sets to adapt to their hosts. However, certain effectors, regarded as core effectors, are conserved among various pathogens, and may therefore play an important and common role in pathogen virulence. We report here that the widely distributed fungal effector NIS1 targets host immune components that transmit signaling from pattern recognition receptors (PRRs) in plants. NIS1 from two Colletotrichum spp. suppressed the hypersensitive response and oxidative burst, both of which are induced by pathogen-derived molecules, in Nicotiana benthamiana. Magnaporthe oryzae NIS1 also suppressed the two defense responses, although this pathogen likely acquired the NIS1 gene via horizontal transfer from Basidiomycota. Interestingly, the root endophyte Colletotrichum tofieldiae also possesses a NIS1 homolog that can suppress the oxidative burst in N. benthamiana. We show that NIS1 of multiple pathogens commonly interacts with the PRR-associated kinases BAK1 and BIK1, thereby inhibiting their kinase activities and the BIK1-NADPH oxidase interaction. Furthermore, mutations in the NIS1-targeting proteins, i.e., BAK1 and BIK1, in Arabidopsis thaliana also resulted in reduced immunity to Colletotrichum fungi. Finally, M. oryzae lacking NIS1 displayed significantly reduced virulence on rice and barley, its hosts. Our study therefore reveals that a broad range of filamentous fungi maintain and utilize the core effector NIS1 to establish infection in their host plants and perhaps also beneficial interactions, by targeting conserved and central PRR-associated kinases that are also known to be targeted by bacterial effectors.
Description: 広範囲の植物病原糸状菌が分泌する感染因子の機能を解明 --エフェクターNIS1は植物の病原体認識システムの中枢を攻撃する--. 京都大学プレスリリース. 2019-01-08.
Rights: © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
URI: http://hdl.handle.net/2433/235959
DOI(Published Version): 10.1073/pnas.1807297116
PubMed ID: 30584105
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2019-01-08-0
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