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dc.contributor.authorFan, Qiaoen
dc.contributor.authorVerhoeven, Virginie J. M.en
dc.contributor.authorWojciechowski, Roberten
dc.contributor.authorBarathi, Veluchamy A.en
dc.contributor.authorHysi, Pirro G.en
dc.contributor.authorGuggenheim, Jeremy A.en
dc.contributor.authorHöhn, Renéen
dc.contributor.authorVitart, Veroniqueen
dc.contributor.authorKhawaja, Anthony P.en
dc.contributor.authorYamashiro, Kenjien
dc.contributor.authorHosseini, S Mohsenen
dc.contributor.authorLehtimäki, Terhoen
dc.contributor.authorLu, Yien
dc.contributor.authorHaller, Toomasen
dc.contributor.authorXie, Jingen
dc.contributor.authorDelcourt, Cécileen
dc.contributor.authorPirastu, Marioen
dc.contributor.authorWedenoja, Juhoen
dc.contributor.authorGharahkhani, Puyaen
dc.contributor.authorVenturini, Cristinaen
dc.contributor.authorMiyake, Masahiroen
dc.contributor.authorHewitt, Alex W.en
dc.contributor.authorGuo, Xiaoboen
dc.contributor.authorMazur, Johannaen
dc.contributor.authorHuffman, Jenifer E.en
dc.contributor.authorWilliams, Katie M.en
dc.contributor.authorPolasek, Ozrenen
dc.contributor.authorCampbell, Harryen
dc.contributor.authorRudan, Igoren
dc.contributor.authorVatavuk, Zoranen
dc.contributor.authorWilson, James F.en
dc.contributor.authorJoshi, Peter K.en
dc.contributor.authorMcMahon, Georgeen
dc.contributor.authorSt Pourcain, Beateen
dc.contributor.authorEvans, David M.en
dc.contributor.authorSimpson, Claire L.en
dc.contributor.authorSchwantes-An, Tae-Hwien
dc.contributor.authorIgo, Robert P.en
dc.contributor.authorMirshahi, Alirezaen
dc.contributor.authorCougnard-Gregoire, Audreyen
dc.contributor.authorBellenguez, Célineen
dc.contributor.authorBlettner, Mariaen
dc.contributor.authorRaitakari, Ollien
dc.contributor.authorKähönen, Mikaen
dc.contributor.authorSeppälä, Ilkkaen
dc.contributor.authorZeller, Tanjaen
dc.contributor.authorMeitinger, Thomasen
dc.contributor.authorRied, Janina S.en
dc.contributor.authorGieger, Christianen
dc.contributor.authorPortas, Lauraen
dc.contributor.authorvan Leeuwen, Elisabeth M.en
dc.contributor.authorAmin, Najafen
dc.contributor.authorUitterlinden, André G.en
dc.contributor.authorRivadeneira, Fernandoen
dc.contributor.authorHofman, Alberten
dc.contributor.authorVingerling, Johannes R.en
dc.contributor.authorWang, Ya Xingen
dc.contributor.authorWang, Xuen
dc.contributor.authorTai-Hui Boh, Eileenen
dc.contributor.authorIkram, M. Kamranen
dc.contributor.authorSabanayagam, Charumathien
dc.contributor.authorGupta, Preetien
dc.contributor.authorTan, Vincenten
dc.contributor.authorZhou, Leien
dc.contributor.authorHo, Candice E. H.en
dc.contributor.authorLim, Wan’een
dc.contributor.authorBeuerman, Roger W.en
dc.contributor.authorSiantar, Rosalynnen
dc.contributor.authorTai, E-Shyongen
dc.contributor.authorVithana, Erangaen
dc.contributor.authorMihailov, Evelinen
dc.contributor.authorKhor, Chiea-Chuenen
dc.contributor.authorHayward, Carolineen
dc.contributor.authorLuben, Robert N.en
dc.contributor.authorFoster, Paul J.en
dc.contributor.authorKlein, Barbara E. K.en
dc.contributor.authorKlein, Ronalden
dc.contributor.authorWong, Hoi-Suenen
dc.contributor.authorMitchell, Paulen
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorAung, Tinen
dc.contributor.authorYoung, Terri L.en
dc.contributor.authorHe, Mingguangen
dc.contributor.authorPärssinen, Olavien
dc.contributor.authorvan Duijn, Cornelia M.en
dc.contributor.authorJin Wang, Jieen
dc.contributor.authorWilliams, Cathyen
dc.contributor.authorJonas, Jost B.en
dc.contributor.authorTeo, Yik-Yingen
dc.contributor.authorMackey, David A.en
dc.contributor.authorOexle, Konraden
dc.contributor.authorYoshimura, Nagahisaen
dc.contributor.authorPaterson, Andrew D.en
dc.contributor.authorPfeiffer, Norberten
dc.contributor.authorWong, Tien-Yinen
dc.contributor.authorBaird, Paul N.en
dc.contributor.authorStambolian, Dwighten
dc.contributor.authorWilson, Joan E. Baileyen
dc.contributor.authorCheng, Ching-Yuen
dc.contributor.authorHammond, Christopher J.en
dc.contributor.authorKlaver, Caroline C. W.en
dc.contributor.authorSaw, Seang-Meien
dc.contributor.alternative山城, 健児ja
dc.contributor.alternative三宅, 正裕ja
dc.contributor.alternative吉村, 長久ja
dc.date.accessioned2019-01-10T01:00:34Z-
dc.date.available2019-01-10T01:00:34Z-
dc.date.issued2016-04-06-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/2433/236005-
dc.description.abstractMyopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40, 036 adults from 25 studies of European ancestry and 10, 315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10−5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Nature America, Incen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectEducationen
dc.subjectGenetic variationen
dc.subjectGenome-wide association studiesen
dc.subjectRefractive errorsen
dc.titleMeta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive erroren
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleNature Communicationsen
dc.identifier.volume7-
dc.identifier.spage11008-
dc.relation.doi10.1038/ncomms11008-
dc.textversionpublisher-
dc.identifier.pmid27020472-
dcterms.accessRightsopen access-
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