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dc.contributor.author | Asamitsu, Sefan | en |
dc.contributor.author | Obata, Shunsuke | en |
dc.contributor.author | Yu, Zutao | en |
dc.contributor.author | Bando, Toshikazu | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | 朝光, 世煌 | ja |
dc.contributor.alternative | 小幡, 俊介 | ja |
dc.contributor.alternative | 余, 祖滔 | ja |
dc.contributor.alternative | 板東, 俊和 | ja |
dc.contributor.alternative | 杉山, 弘 | ja |
dc.date.accessioned | 2019-02-04T07:52:25Z | - |
dc.date.available | 2019-02-04T07:52:25Z | - |
dc.date.issued | 2019-01-24 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2433/236180 | - |
dc.description.abstract | A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | NLM (Medline) | en |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) | en |
dc.subject | cancer therapy | en |
dc.subject | telomere | en |
dc.subject | oncogenes | en |
dc.subject | G-quadruplex | en |
dc.subject | selective ligands | en |
dc.title | Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Molecules | en |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 3 | - |
dc.relation.doi | 10.3390/molecules24030429 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 429 | - |
dc.address | Department of Chemistry, Graduate School of Science Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science Kyoto University | en |
dc.address | Department of Chemistry, Graduate School of Science Kyoto University・Institute for Integrated Cell-Material Science (WPI-iCeMS) Kyoto University | en |
dc.identifier.pmid | 30682877 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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