ダウンロード数: 206
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s41598-018-36066-z.pdf | 2.19 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Nagao, Kazuya | en |
dc.contributor.author | Taniguchi, Tomohiko | en |
dc.contributor.author | Morimoto, Takeshi | en |
dc.contributor.author | Shiomi, Hiroki | en |
dc.contributor.author | Ando, Kenji | en |
dc.contributor.author | Kanamori, Norio | en |
dc.contributor.author | Murata, Koichiro | en |
dc.contributor.author | Kitai, Takeshi | en |
dc.contributor.author | Kawase, Yuichi | en |
dc.contributor.author | Izumi, Chisato | en |
dc.contributor.author | Miyake, Makoto | en |
dc.contributor.author | Mitsuoka, Hirokazu | en |
dc.contributor.author | Kato, Masashi | en |
dc.contributor.author | Hirano, Yutaka | en |
dc.contributor.author | Matsuda, Shintaro | en |
dc.contributor.author | Inada, Tsukasa | en |
dc.contributor.author | Murakami, Tomoyuki | en |
dc.contributor.author | Takeuchi, Yasuyo | en |
dc.contributor.author | Yamane, Keiichiro | en |
dc.contributor.author | Toyofuku, Mamoru | en |
dc.contributor.author | Ishii, Mitsuru | en |
dc.contributor.author | Minamino-Muta, Eri | en |
dc.contributor.author | Kato, Takao | en |
dc.contributor.author | Inoko, Moriaki | en |
dc.contributor.author | Ikeda, Tomoyuki | en |
dc.contributor.author | Komasa, Akihiro | en |
dc.contributor.author | Ishii, Katsuhisa | en |
dc.contributor.author | Hotta, Kozo | en |
dc.contributor.author | Higashitani, Nobuya | en |
dc.contributor.author | Kato, Yoshihiro | en |
dc.contributor.author | Inuzuka, Yasutaka | en |
dc.contributor.author | Maeda, Chiyo | en |
dc.contributor.author | Jinnai, Toshikazu | en |
dc.contributor.author | Morikami, Yuko | en |
dc.contributor.author | Saito, Naritatsu | en |
dc.contributor.author | Minatoya, Kenji | en |
dc.contributor.author | Kimura, Takeshi | en |
dc.contributor.author | CURRENT AS Registry Investigators | en |
dc.contributor.alternative | 加藤, 貴雄 | ja |
dc.contributor.alternative | 齋藤, 成達 | ja |
dc.contributor.alternative | 木村, 剛 | ja |
dc.date.accessioned | 2019-02-20T07:37:52Z | - |
dc.date.available | 2019-02-20T07:37:52Z | - |
dc.date.issued | 2019-02-13 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/236492 | - |
dc.description.abstract | Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.subject | Outcomes research | en |
dc.subject | Valvular disease | en |
dc.title | Anemia in Patients with Severe Aortic Stenosis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 9 | - |
dc.relation.doi | 10.1038/s41598-018-36066-z | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 1924 | - |
dc.identifier.pmid | 30760807 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2045-2322 | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。