ダウンロード数: 236
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.celrep.2019.02.009.pdf | 9.62 MB | Adobe PDF | 見る/開く |
タイトル: | Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor |
著者: | Terada, Yukinori Jo, Norihide https://orcid.org/0000-0002-9661-4546 (unconfirmed) Arakawa, Yoshiki https://orcid.org/0000-0003-4626-4645 (unconfirmed) Sakakura, Megumi Yamada, Yosuke https://orcid.org/0000-0001-7952-2706 (unconfirmed) Ukai, Tomoyo Kabata, Mio Mitsunaga, Kanae Mineharu, Yohei https://orcid.org/0000-0002-6346-3999 (unconfirmed) Ohta, Sho Nakagawa, Masato Miyamoto, Susumu Yamamoto, Takuya https://orcid.org/0000-0002-0022-3947 (unconfirmed) Yamada, Yasuhiro |
著者名の別形: | 寺田, 行範 城, 憲秀 荒川, 芳輝 坂倉, 恵 山田, 洋介 鵜飼, 智代 蒲田, 未央 光永, 佳奈枝 峰晴, 陽平 太田, 翔 中川, 誠人 宮本, 享 山本, 拓也 山田, 泰広 |
キーワード: | atypical teratoid/rhabdoid tumor pediatric tumor embryonic stem cell induced pluripotent stem cell ESC-like signature pluripotency dedifferentiation SMARCB1 |
発行日: | 5-Mar-2019 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 26 |
号: | 10 |
開始ページ: | 2608 |
終了ページ: | 2621.e6 |
抄録: | Atypical teratoid/rhabdoid tumor (AT/RT), which harbors SMARCB1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatments. Here, we establish human SMARCB1-deficient pluripotent stem cells (hPSCs). SMARCB1-deficient hPSC-derived neural progenitor-like cells (NPLCs) efficiently give rise to brain tumors when transplanted into the mouse brain. Notably, activation of an embryonic stem cell (ESC)-like signature confers a rhabdoid histology in SMARCB1-deficient NPLC-derived tumors and causes a poor prognosis. Consistently, we find the activation of the ESC-like gene expression signature and an ESC-like DNA methylation landscape in clinical specimens of AT/RT. Finally, we identify candidate genes that maintain the activation of the ESC-like signature and the growth of AT/RT cells. Collectively, SMARCB1-deficient hPSCs offer the human models for AT/RT, which uncover the role of the activated ESC-like signature in the poor prognosis and unique histology of AT/RT. |
記述: | ヒトiPS細胞を使った小児脳腫瘍の病態解明 --新しい治療標的を同定--. 京都大学プレスリリース. 2019-03-06. |
著作権等: | © 2019 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/236705 |
DOI(出版社版): | 10.1016/j.celrep.2019.02.009 |
PubMed ID: | 30840885 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2019-03-06 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。