Downloads: 98

Files in This Item:
File Description SizeFormat 
internalmedicine.1246-18.pdf2.29 MBAdobe PDFView/Open
Title: Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
Authors: Nagano, Masahiro
Ayaki, Takashi  kyouindb  KAKEN_id
Koita, Natsuko
Kitano, Toshiyuki
Nishikori, Momoko  kyouindb  KAKEN_id
Goda, Naoki
Minamiguchi, Sachiko  kyouindb  KAKEN_id
Ikeda, Akio
Takaori-Kondo, Akifumi
Takahashi, Ryosuke  kyouindb  KAKEN_id
Author's alias: 綾木, 孝
北野, 俊行
錦織, 桃子
合田, 直樹
南口, 早智子
池田, 昭夫
髙折, 晃史
高橋, 良輔
Keywords: primary central nervous system lymphoma (PCNSL)
chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
recurrence
repeat brain biopsy, Epstein-Barr virus (EBV)
Issue Date: 15-Mar-2019
Publisher: Japanese Society of Internal Medicine
Journal title: Internal Medicine
Volume: 58
Issue: 6
Start page: 849
End page: 854
Abstract: Primary central nervous system lymphoma (PCNSL) and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) can share clinical features and may be indistinguishable, even after brain biopsy. We encountered a case of Epstein-Barr virus-positive (EBV+) PCNSL recurrence in a patient with clinical features of CLIPPERS, and repeat brain biopsy was required to reach the correct diagnosis. Four years after the initial diagnosis and treatment of PCNSL, "peppering" punctate enhanced lesions with transient steroid responsiveness were detected during brain magnetic resonance imaging (MRI). A second brain biopsy supported a diagnosis of CLIPPERS, while a third biopsy confirmed the diagnosis of recurrent PCNSL.
Rights: The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/ by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/240900
DOI(Published Version): 10.2169/internalmedicine.1246-18
PubMed ID: 30880301
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.