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DCフィールド | 値 | 言語 |
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dc.contributor.author | Yamamoto, Koki | en |
dc.contributor.author | Inuki, Shinsuke | en |
dc.contributor.author | Ohno, Hiroaki | en |
dc.contributor.author | Oishi, Shinya | en |
dc.contributor.alternative | 井貫, 晋輔 | ja |
dc.contributor.alternative | 大野, 浩章 | ja |
dc.contributor.alternative | 大石, 真也 | ja |
dc.date.accessioned | 2019-04-26T05:52:08Z | - |
dc.date.available | 2019-04-26T05:52:08Z | - |
dc.date.issued | 2019-05-15 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | http://hdl.handle.net/2433/241057 | - |
dc.description.abstract | Neurokinin-3 receptor (NK3R) plays a pivotal role in the release of gonadotropin-releasing hormone in the hypothalamus–pituitary–gonadal (HPG) axis. To develop novel NK3R antagonists with less environmental toxicity, a series of heterocyclic scaffolds for the triazolopiperazine substructure in an NK3R antagonist fezolinetant were designed and synthesized. An isoxazolo[3, 4–c]piperidine derivative exhibited moderate NK3R antagonistic activity and favorable properties that were decomposable under environmental conditions. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en |
dc.rights | The full-text file will be made open to the public on 15 May 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Environmental impact | en |
dc.subject | Fezolinetant | en |
dc.subject | GnRH | en |
dc.subject | NK3 receptor | en |
dc.subject | Scaffold hopping | en |
dc.title | Scaffold hopping of fused piperidine-type NK3 receptor antagonists to reduce environmental impact | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10938083 | - |
dc.identifier.jtitle | Bioorganic & Medicinal Chemistry | en |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 2019 | - |
dc.identifier.epage | 2026 | - |
dc.relation.doi | 10.1016/j.bmc.2019.03.059 | - |
dc.textversion | author | - |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.identifier.pmid | 30975505 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2021-05-15 | - |
datacite.awardNumber | 17J10582 | - |
dc.identifier.pissn | 0968-0896 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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