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dc.contributor.authorYonezawa, Atushien
dc.contributor.authorOtani, Yukien
dc.contributor.authorKitano, Toshiyukien
dc.contributor.authorMori, Mayukoen
dc.contributor.authorMasui, Shoen
dc.contributor.authorIsomoto, Yuien
dc.contributor.authorTsuda, Masahiroen
dc.contributor.authorImai, Satoshien
dc.contributor.authorIkemi, Yasuakien
dc.contributor.authorDenda, Masayaen
dc.contributor.authorSato, Yukien
dc.contributor.authorNakagawa, Shunsakuen
dc.contributor.authorOmura, Tomohiroen
dc.contributor.authorNakagawa, Takayukien
dc.contributor.authorYano, Ikukoen
dc.contributor.authorHayakari, Makotoen
dc.contributor.authorTakaori-Kondo, Akifumien
dc.contributor.authorMatsubara, Kazuoen
dc.contributor.alternative米澤, 淳ja
dc.contributor.alternative北野, 俊行ja
dc.contributor.alternative津田, 真弘ja
dc.contributor.alternative中川, 俊作ja
dc.contributor.alternative大村, 友博ja
dc.contributor.alternative矢野, 育子ja
dc.contributor.alternative髙折, 晃史ja
dc.contributor.alternative松原, 和夫ja
dc.date.accessioned2019-05-10T07:10:25Z-
dc.date.available2019-05-10T07:10:25Z-
dc.date.issued2019-06-
dc.identifier.issn0724-8741-
dc.identifier.issn1573-904X-
dc.identifier.urihttp://hdl.handle.net/2433/241257-
dc.description.abstractPurpose: Therapeutic antibodies have heterogeneities in their structures, although its structural alteration in the body is unclear. Here, we analyzed the change of amino acid modifications and carbohydrate chains of rituximab after administration to patients. Methods: Twenty B cell non-Hodgkin’s lymphoma patients who were treated with rituximab for the first time or after more than one year’s abstinence were recruited. Structural analysis of rituximab was carried out at 1 h after administration and at the trough by using liquid chromatography/time-of-flight-mass spectrometry. Plasma rituximab concentration and pharmacodynamic markers were also determined. Results: Of recruited twenty, 3 patients exhibited rapid rituximab clearance. Nine types of carbohydrate chains were detected in rituximab isolated from the blood. The composition ratios in some glycoforms were significantly different between at 1 h after administration and at the trough, although consisted amino acids remained unchanged. The patients with high clearance showed extensive alterations of glycoform composition ratios. However, pharmacodynamics makers were not different. Conclusion: Inter-individual variations in plasma concentrations of rituximab were found in some B-NHL patients. We could analyze a change in glycoforms of rituximab in the patients, and this finding may affect the pharmacokinetics of rituximab.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Pharmaceutical Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11095-019-2624-5.en
dc.rightsThe full-text file will be made open to the public on 15 April 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.rightsThis is not the published version. Please cite only the published version.en
dc.subjectcarbohydrate chainen
dc.subjectLC/TOF-MSen
dc.subjectpharmacokineticsen
dc.subjectrituximaben
dc.subjecttherapeutic monoclonal antibodyen
dc.titleConcentration and Glycoform of Rituximab in Plasma of Patients with B Cell Non-Hodgkin’s Lymphomaen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA10632083-
dc.identifier.jtitlePharmaceutical researchen
dc.identifier.volume36-
dc.relation.doi10.1007/s11095-019-2624-5-
dc.textversionauthor-
dc.identifier.artnum82-
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University・Department of HematologyKitano Hospital, Osakaen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital・Graduate School of Pharmaceutical Sciences, Kyoto University・Department of Pharmacy, Kobe University Hospitalen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto Universityen
dc.addressDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospitalen
dc.identifier.pmid30989405-
dcterms.accessRightsopen access-
datacite.date.available2020-04-15-
dc.identifier.pissn0724-8741-
dc.identifier.eissn1573-904X-
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