Access count of this item: 42

Files in This Item:
File Description SizeFormat 
j.jtbi.2019.04.008.pdf450.59 kBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTsuruyama, Tatsuaki
dc.contributor.alternative鶴山, 竜昭
dc.date.accessioned2019-05-20T06:03:40Z-
dc.date.available2019-05-20T06:03:40Z-
dc.date.issued2019-07-07
dc.identifier.issn0022-5193
dc.identifier.issn1095-8541
dc.identifier.urihttp://hdl.handle.net/2433/241544-
dc.description.abstractStudies have reported that bio-cellular signal transduction can be investigated based on thermodynamics. This short article aims to consider signal transduction carried out by signaling molecules from the perspective of non-equilibrium thermodynamics. Under conditions in which total entropy production rate was minimized, the entropy production rate per signaling molecule was conserved independently of the steps during signal transduction. Accordingly, the conserved production rate can be defined as the channel capacity of the given signal transduction cascade. Non- equilibrium thermodynamics provides a theoretical framework for cell signal transduction.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAcademic Press
dc.rights© 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.subjectSignal transduction
dc.subjectNon-equilibrium linear thermodynamics
dc.subjectEntropy production rate
dc.titleNon-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate
dc.type.niitypeJournal Article
dc.identifier.jtitleJournal of Theoretical Biology
dc.identifier.volume472
dc.identifier.spage84
dc.identifier.epage87
dc.relation.doi10.1016/j.jtbi.2019.04.008
dc.textversionpublisher
dc.addressDepartment of Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University
dc.identifier.pmid30978350
Appears in Collections:Journal Articles

Show simple item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.