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j.jtbi.2019.04.008.pdf | 450.59 kB | Adobe PDF | 見る/開く |
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dc.contributor.author | Tsuruyama, Tatsuaki | en |
dc.contributor.alternative | 鶴山, 竜昭 | ja |
dc.date.accessioned | 2019-05-20T06:03:40Z | - |
dc.date.available | 2019-05-20T06:03:40Z | - |
dc.date.issued | 2019-07-07 | - |
dc.identifier.issn | 0022-5193 | - |
dc.identifier.issn | 1095-8541 | - |
dc.identifier.uri | http://hdl.handle.net/2433/241544 | - |
dc.description.abstract | Studies have reported that bio-cellular signal transduction can be investigated based on thermodynamics. This short article aims to consider signal transduction carried out by signaling molecules from the perspective of non-equilibrium thermodynamics. Under conditions in which total entropy production rate was minimized, the entropy production rate per signaling molecule was conserved independently of the steps during signal transduction. Accordingly, the conserved production rate can be defined as the channel capacity of the given signal transduction cascade. Non- equilibrium thermodynamics provides a theoretical framework for cell signal transduction. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Academic Press | en |
dc.rights | © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/) | en |
dc.subject | Signal transduction | en |
dc.subject | Non-equilibrium linear thermodynamics | en |
dc.subject | Entropy production rate | en |
dc.title | Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Theoretical Biology | - |
dc.identifier.volume | 472 | - |
dc.identifier.spage | 84 | - |
dc.identifier.epage | 87 | - |
dc.relation.doi | 10.1016/j.jtbi.2019.04.008 | - |
dc.textversion | publisher | - |
dc.address | Department of Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University | en |
dc.identifier.pmid | 30978350 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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