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Title: Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons
Authors: Kawai, Hiroyuki
Asaoka, Nozomi
Miyake, Takahito
Nagayasu, Kazuki
Nakagawa, Takayuki
Shirakawa, Hisashi
Kaneko, Shuji
Author's alias: 河合, 洋幸
淺岡, 希美
三宅, 崇仁
永安, 一樹
中川, 貴之
白川, 久志
金子, 周司
Keywords: Neurotropin
DRG neuron
Voltage-dependent K⁺ channel
Issue Date: Jul-2018
Publisher: Elsevier BV
Journal title: Journal of pharmacological sciences
Volume: 137
Issue: 3
Start page: 313
End page: 316
Abstract: Neurotropin (NTP) is a Japanese analgesic agent for treating neuropathic pain; however, its method of action remains unclear. This study examined the effects of NTP on the activity of small dorsal root ganglion (DRG) neurons using whole-cell patch clamp recordings. After 3 days of treatment, NTP decreased current injection-induced firing activity of cultured DRG neurons by raising the current threshold for action potential generation. Additionally, NTP increased the sustained component of voltage-gated potassium (Kv) channel currents without affecting other K⁺ currents. These results suggest that NTP inhibits the firing activity of DRG neurons through augmentation of sustained Kv current.
Rights: © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/241622
DOI(Published Version): 10.1016/j.jphs.2018.05.005
PubMed ID: 29907377
Appears in Collections:Journal Articles

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