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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.jphs.2018.05.005.pdf | 1.18 MB | Adobe PDF | 見る/開く |
| タイトル: | Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons |
| 著者: | Kawai, Hiroyuki Asaoka, Nozomi   Miyake, Takahito  https://orcid.org/0000-0002-4356-5883 (unconfirmed)Nagayasu, Kazuki https://orcid.org/0000-0002-7438-732X (unconfirmed)Nakagawa, Takayuki https://orcid.org/0000-0003-1890-0843 (unconfirmed)Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed)Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
| 著者名の別形: | 河合, 洋幸 淺岡, 希美 三宅, 崇仁 永安, 一樹 中川, 貴之 白川, 久志 金子, 周司 |
| キーワード: | Neurotropin DRG neuron Voltage-dependent K⁺ channel |
| 発行日: | Jul-2018 |
| 出版者: | Elsevier BV |
| 誌名: | Journal of pharmacological sciences |
| 巻: | 137 |
| 号: | 3 |
| 開始ページ: | 313 |
| 終了ページ: | 316 |
| 抄録: | Neurotropin (NTP) is a Japanese analgesic agent for treating neuropathic pain; however, its method of action remains unclear. This study examined the effects of NTP on the activity of small dorsal root ganglion (DRG) neurons using whole-cell patch clamp recordings. After 3 days of treatment, NTP decreased current injection-induced firing activity of cultured DRG neurons by raising the current threshold for action potential generation. Additionally, NTP increased the sustained component of voltage-gated potassium (Kv) channel currents without affecting other K⁺ currents. These results suggest that NTP inhibits the firing activity of DRG neurons through augmentation of sustained Kv current. |
| 著作権等: | © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| URI: | http://hdl.handle.net/2433/241622 |
| DOI(出版社版): | 10.1016/j.jphs.2018.05.005 |
| PubMed ID: | 29907377 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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