Access count of this item: 17
|Title:||Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair|
|Author's alias:||橋谷, 文貴|
|Journal title:||Bioorganic and Medicinal Chemistry|
|Abstract:||Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine–thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate electron transfer in DNA, and is a useful probe for protein–DNA interaction analysis. In the present study using BrU we found that UV irradiation facilitated electron injection from mitochondrial transcription factor A into DNA. We also observed that this electron injection could lead to repair of a thymine–thymine dimer.|
|Rights:||© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/BY-NC-ND/4.0/).|
|Appears in Collections:||Journal Articles|
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