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Title: Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair
Authors: Hashiya, Fumitaka
Ito, Shinji
Sugiyama, Hiroshi
Author's alias: 橋谷, 文貴
伊藤, 慎二
杉山, 弘
Keywords: Bromouracil
Electron transfer
Issue Date: 15-Jan-2019
Publisher: Elsevier Ltd
Journal title: Bioorganic and Medicinal Chemistry
Volume: 27
Issue: 2
Start page: 278
End page: 284
Abstract: Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine–thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate electron transfer in DNA, and is a useful probe for protein–DNA interaction analysis. In the present study using BrU we found that UV irradiation facilitated electron injection from mitochondrial transcription factor A into DNA. We also observed that this electron injection could lead to repair of a thymine–thymine dimer.
Rights: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(
DOI(Published Version): 10.1016/j.bmc.2018.11.044
PubMed ID: 30552005
Appears in Collections:Journal Articles

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