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dc.contributor.author | Usami, Kiyohide | en |
dc.contributor.author | Korzeniewska, Anna | en |
dc.contributor.author | Matsumoto, Riki | en |
dc.contributor.author | Kobayashi, Katsuya | en |
dc.contributor.author | Hitomi, Takefumi | en |
dc.contributor.author | Matsuhashi, Masao | en |
dc.contributor.author | Kunieda, Takeharu | en |
dc.contributor.author | Mikuni, Nobuhiro | en |
dc.contributor.author | Kikuchi, Takayuki | en |
dc.contributor.author | Yoshida, Kazumichi | en |
dc.contributor.author | Miyamoto, Susumu | en |
dc.contributor.author | Takahashi, Ryosuke | en |
dc.contributor.author | Ikeda, Akio | en |
dc.contributor.author | Crone, Nathan E | en |
dc.contributor.alternative | 宇佐美, 清英 | ja |
dc.contributor.alternative | 松本, 理器 | ja |
dc.contributor.alternative | 小林, 勝哉 | ja |
dc.contributor.alternative | 人見, 健文 | ja |
dc.contributor.alternative | 松橋, 眞生 | ja |
dc.contributor.alternative | 國枝, 武治 | ja |
dc.contributor.alternative | 三國, 信啓 | ja |
dc.contributor.alternative | 菊池, 隆幸 | ja |
dc.contributor.alternative | 吉田, 和道 | ja |
dc.contributor.alternative | 宮本, 享 | ja |
dc.contributor.alternative | 髙橋, 良輔 | ja |
dc.contributor.alternative | 池田, 昭夫 | ja |
dc.date.accessioned | 2019-06-25T07:43:32Z | - |
dc.date.available | 2019-06-25T07:43:32Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0161-8105 | - |
dc.identifier.issn | 1550-9109 | - |
dc.identifier.uri | http://hdl.handle.net/2433/242231 | - |
dc.description.abstract | Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing vs planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality analysis (ERC), we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press (OUP) | en |
dc.rights | This is a pre-copyedited, author-produced PDF of an article accepted for publication in 'Sleep' following peer review. The version of record [Sleep, Volume 42, Issue 6, June 2019, zsz050] is available online at: https://doi.org/10.1093/sleep/zsz050 | en |
dc.rights | The full-text file will be made open to the public on 22 February 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | brain waves | en |
dc.subject | human electrocorticography | en |
dc.subject | high-gamma activity | en |
dc.subject | effective connectivity | en |
dc.subject | causal interactions | en |
dc.title | The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Sleep | - |
dc.identifier.volume | 42 | - |
dc.identifier.issue | 6 | - |
dc.relation.doi | 10.1093/sleep/zsz050 | - |
dc.textversion | author | - |
dc.identifier.artnum | zsz050 | - |
dc.identifier.pmid | 30794319 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-02-22 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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