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DCフィールド | 値 | 言語 |
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dc.contributor.author | Teramoto, Koji | en |
dc.contributor.author | Katoh, Hironori | en |
dc.contributor.alternative | 加藤, 裕教 | ja |
dc.date.accessioned | 2019-07-12T06:20:11Z | - |
dc.date.available | 2019-07-12T06:20:11Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.issn | 1873-3913 | - |
dc.identifier.uri | http://hdl.handle.net/2433/242982 | - |
dc.description.abstract | EphA2, which belongs to the Eph family of receptor tyrosine kinases, is overexpressed in a variety of human cancers. Serine 897 (S897) phosphorylation of EphA2 is known to promote cancer cell migration and proliferation in a ligand-independent manner. In this study, we show that glucose deprivation induces S897 phosphorylation of EphA2 in glioblastoma cells. The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. Furthermore, depletion of EphA2 in glioblastoma cells leads to decreased cell viability under glucose starvation. Our results suggest a role of EphA2 in glioblastoma cell viability under glucose-limited conditions. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en |
dc.rights | The full-text file will be made open to the public on 1 October 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | EphA2 | en |
dc.subject | xCT | en |
dc.subject | Amino acid transporter | en |
dc.subject | RSK | en |
dc.subject | Glioblastoma | en |
dc.subject | Glucose | en |
dc.title | The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cellular Signalling | en |
dc.identifier.volume | 62 | - |
dc.relation.doi | 10.1016/j.cellsig.2019.05.014 | - |
dc.textversion | author | - |
dc.identifier.artnum | 109329 | - |
dc.address | Laboratory of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Laboratory of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University・Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University | en |
dc.identifier.pmid | 31152846 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-10-01 | - |
datacite.awardNumber | 18K06215 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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