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Title: Direct Dehydroxylative Coupling Reaction of Alcohols with Organosilanes through Si–X Bond Activation by Halogen Bonding
Authors: Saito, Masato
Tsuji, Nobuya
Kobayashi, Yusuke
Takemoto, Yoshiji
Author's alias: 小林, 祐輔
竹本, 佳司
Issue Date: 19-Jun-2015
Publisher: American Chemical Society (ACS)
Journal title: Organic Letters
Volume: 17
Issue: 12
Start page: 3000
End page: 3003
Abstract: The combined use of a halogen bond (XB) donor with trimethylsilyl halide was found to be an efficient cocatalytic system for the direct dehydroxylative coupling reaction of alcohol with various nucleophiles, such as allyltrimethylsilane and trimethylcyanide, to give the corresponding adduct in moderate to excellent yields. Detailed control experiments and mechanistic studies revealed that the XB interaction was crucial for the reaction. The application of this coupling reaction is also described.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'Organic Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
The full-text file will be made open to the public on 28 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1021/acs.orglett.5b01290
PubMed ID: 26020103
Appears in Collections:Journal Articles

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