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Title: Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction
Authors: Takemoto, Yoshiji
March, Taryn
Murata, Akihiro
Kobayashi, Yusuke
Author's alias: 竹本, 佳司
小林, 祐輔
Keywords: bifunctional organocatalyst
cinchona alkaloid
malonic acid half oxyester (MAHO)
β-hydroxy-α-amino acid
Issue Date: Jul-2017
Publisher: Georg Thieme Verlag
Journal title: Synlett
Volume: 28
Issue: 11
Start page: 1295
End page: 1299
Abstract: The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the β-hydroxy-α-amino acid derivatives in moderate to high yields and with high enantioselectivities.
Rights: This is the accepted manuscript of the article, which has been published in final form at
The full-text file will be made open to the public on 2 March 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1055/s-0036-1588141
Appears in Collections:Journal Articles

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