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dc.contributor.authorOkitsu, Takashien
dc.contributor.authorMatsuyama, Takeen
dc.contributor.authorYamashita, Takahiroen
dc.contributor.authorIshizuka, Toruen
dc.contributor.authorYawo, Hiromuen
dc.contributor.authorImamoto, Yasushien
dc.contributor.authorShichida, Yoshinorien
dc.contributor.authorWada, Akimorien
dc.contributor.alternative山下, 高廣ja
dc.contributor.alternative今元, 泰ja
dc.contributor.alternative七田, 芳則ja
dc.date.accessioned2019-07-23T01:10:39Z-
dc.date.available2019-07-23T01:10:39Z-
dc.date.issued2017-04-01-
dc.identifier.issn0009-2363-
dc.identifier.issn1347-5223-
dc.identifier.urihttp://hdl.handle.net/2433/243170-
dc.description.abstractRed-shifted channelrhodopsins (ChRs) are attractive for optogenetic tools. We developed a new type of red-shifted ChRs that utilized noncovalent incorporation of retinal and 3, 4-dehydroretinal-based enamine-type Schiff bases and mutated channelopsin, C1C2-K296G. These ChRs exhibited absorption maxima that were shifted 10–30 nm toward longer wavelengths than that of C1C2-ChR regenerated with all-trans-retinal.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPharmaceutical Society of Japanen
dc.publisher.alternative日本薬学会ja
dc.rights© 2017 The Pharmaceutical Society of Japanen
dc.rights許諾条件に基づいて掲載しています。ja
dc.subjectchannelrhodopsinen
dc.subjectchromophoreen
dc.subjectred-shiften
dc.subjectneuroscienceen
dc.subjectoptogeneticsen
dc.titleAlternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsinen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA00602100-
dc.identifier.jtitleChemical and Pharmaceutical Bulletinen
dc.identifier.volume65-
dc.identifier.issue4-
dc.identifier.spage356-
dc.identifier.epage358-
dc.relation.doi10.1248/cpb.c17-00054-
dc.textversionpublisher-
dc.addressDepartment of Organic Chemistry for Life Science, Kobe Pharmaceutical Universityen
dc.addressRetinal Regeneration Lab, RIKEN Center for Developmental Biologyen
dc.addressDepartment of Biophysics, Graduate School of Science, Kyoto Universityen
dc.addressDepartment of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku Universityen
dc.addressDepartment of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku Universityen
dc.addressDepartment of Biophysics, Graduate School of Science, Kyoto Universityen
dc.addressDepartment of Biophysics, Graduate School of Science, Kyoto Universityen
dc.addressDepartment of Organic Chemistry for Life Science, Kobe Pharmaceutical Universityen
dc.identifier.pmid28381675-
dc.relation.NAID130005529782-
dcterms.accessRightsopen access-
datacite.awardNumber26450146-
dc.identifier.pissn0009-2363-
dc.identifier.eissn1347-5223-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
出現コレクション:学術雑誌掲載論文等

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