Downloads: 0

Files in This Item:
This article will be available after a certain embargo period.
Please see the "Rights" information in item metadata display about embargo date.
Title: Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response
Authors: Onishi, Toshinori
Honda, Akiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Tanaka, Michitaka
Chowdhury, Pratiti H.
Okano, Hitoshi
Okuda, Tomoaki
Shishido, Daiki
Terui, Yoshihiro
Hasegawa, Shuichi
Kameda, Takayuki  kyouindb  KAKEN_id
Tohno, Susumu  kyouindb  KAKEN_id
Hayashi, Masahiko
Nishita-Hara, Chiharu
Hara, Keiichiro
Inoue, Kozo
Yasuda, Makoto
Hirano, Shigeru
Takano, Hirohisa  kyouindb  KAKEN_id
Author's alias: 本田, 晶子
亀田, 貴之
高野, 裕久
Keywords: Ambient particulate matter
Cyclone technique
Respiratory cellsImmune cells
Inflammatory responses
Issue Date: Nov-2018
Publisher: Elsevier BV
Journal title: Environmental Pollution
Volume: 242
Issue: Part B
Start page: 1693
End page: 1701
Abstract: Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 1 November 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.envpol.2018.07.103
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks

Export Format: 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.