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DCフィールド | 値 | 言語 |
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dc.contributor.author | Endo, Kei | en |
dc.contributor.author | Hayashi, Karin | en |
dc.contributor.author | Saito, Hirohide | en |
dc.contributor.alternative | 遠藤, 慧 | ja |
dc.contributor.alternative | 林, 香倫 | ja |
dc.contributor.alternative | 齊藤, 博英 | ja |
dc.date.accessioned | 2019-09-02T00:10:32Z | - |
dc.date.available | 2019-09-02T00:10:32Z | - |
dc.date.issued | 2019-08-02 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2433/243837 | - |
dc.description | 細胞内の複数のマイクロRNAを同時に検知して細胞を生きたまま精密に分けることに成功. 京都大学プレスリリース. 2019-08-30. | ja |
dc.description.abstract | Integrated bioengineering systems can make executable decisions according to the cell state. To sense the state, multiple biomarkers are detected and processed via logic gates with synthetic biological devices. However, numerical operations have not been achieved. Here, we show a design principle for messenger RNA (mRNA) devices that recapitulates intracellular information by multivariate calculations in single living cells. On the basis of this principle and the collected profiles of multiple microRNA activities, we demonstrate that rationally programmed mRNA sets classify living human cells and track their change during differentiation. Our mRNA devices automatically perform multivariate calculation and function as a decision-maker in response to dynamic intracellular changes in living cells. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | en |
dc.rights | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.title | Numerical operations in living cells by programmable RNA devices | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science Advances | en |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 8 | - |
dc.relation.doi | 10.1126/sciadv.aax0835 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | eaax0835 | - |
dc.address | Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University・Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo | en |
dc.address | Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University | en |
dc.address | Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University | en |
dc.identifier.pmid | 31457099 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2019-08-30-0 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 15H05722 | - |
datacite.awardNumber | 25870355 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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