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Title: hCG陽性細胞を含む分類不能型性索間質性精巣腫瘍の1例
Other Titles: A Case of Unclassified Sex Cord-Stromal Tumor Containing hCG-Positive Cells
Authors: 鳥山, 風夏  KAKEN_name
奥野, 佑美子  KAKEN_name
三上, 耕治  KAKEN_name
植草, 利公  KAKEN_name
武内, 巧  KAKEN_name
Author's alias: Toriyama, Fuka
Okuno, Yumiko
Mikami, Koji
Uekusa, Toshimasa
Takeuchi, Takumi
Keywords: Unclassified sex cord-stromal tumor
Testicular tumor
Issue Date: 31-Aug-2019
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要 = Acta urologica Japonica
Volume: 65
Issue: 8
Start page: 347
End page: 350
Abstract: We present a case of unclassified sex cord-stromal testicular tumor with lung metastasis. A 48-year-old man consulted our hospital for left testicular enlargement that began 3 years ago. Computed tomography revealed a heterogeneously enhanced left testicular tumor 11 cm in diameter and a 5 mm metastatic lung tumor. The human chorionic gonadotropin (hCG) level was elevated (141.6 mU/ml), whereas the levels of α-fetoprotein (AFP) and LDH were normal. The external genitalia were normal and gynecomastia was not observed. Left high orchiectomy followed by 3 cycles of BEP chemotherapy (bleomycin, etoposide, and cisplatin) every 4 weeks was performed. The pathology of the excised specimen was unclassified sex cordstromal testicular tumor containing hCG-positive cells. On immunohistochemistry, the tumor cells were partly positive for AE1/AE3, hCG, and calretinin. Vimentin was diffusely positive, but OCT3/4, SALL4, GATA3, and CK7 were negative. After BEP treatment, the metastatic lung lesion disappeared. Unclassified sex cord-stromal testicular tumor is a rare disease and its treatment has not been established. Thus, further accumulation of cases is needed.
Rights: 許諾条件により本文は2020/09/01に公開
DOI: 10.14989/ActaUrolJap_65_8_347
PubMed ID: 31501405
Appears in Collections:Vol.65 No.8

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