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DCフィールド | 値 | 言語 |
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dc.contributor.author | Arichi, Norihito | en |
dc.contributor.author | Hata, Kenji | en |
dc.contributor.author | Takemoto, Yoshiji | en |
dc.contributor.author | Yamada, Ken-ichi | en |
dc.contributor.author | Yamaoka, Yousuke | en |
dc.contributor.author | Takasu, Kiyosei | en |
dc.contributor.alternative | 有地, 法人 | ja |
dc.contributor.alternative | 竹本, 佳司 | ja |
dc.contributor.alternative | 山田, 健一 | ja |
dc.contributor.alternative | 山岡, 陽介 | ja |
dc.contributor.alternative | 高須, 清誠 | ja |
dc.date.accessioned | 2019-09-11T06:28:04Z | - |
dc.date.available | 2019-09-11T06:28:04Z | - |
dc.date.issued | 2015-01-14 | - |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.uri | http://hdl.handle.net/2433/243966 | - |
dc.description.abstract | Fixing conformation by introducing a ring structure is a common strategy in drug development. We demonstrate a synthesis that installs a small carbocyclic ring as a structurally-rigid unit in drug lead compounds. Both trans- and cis-cyclobutane rings were constructed in excellent selectivities by controlling the reaction temperature of an EtAlCl2-catalyzed [2+2] cycloaddition between a silyl enol ether and an α, β-unsaturated ester. Spirocyclopropane rings were stereospecifically formed by our previously reported ring-contraction rearrangement of fused cyclobutanols. This strategy allowed stereodivergent access to a new class of steroidal derivatives bearing a small ring. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights | The full-text file will be made open to the public on 14 January 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Steroids | en |
dc.subject | Cyclopropanes | en |
dc.subject | Cyclobutanes | en |
dc.subject | [2+2] Cycloaddition | en |
dc.subject | Ring contraction | en |
dc.title | Synthesis of steroidal derivatives bearing a small ring using a catalytic [2+2] cycloaddition and a ring-contraction rearrangement | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00861787 | - |
dc.identifier.jtitle | Tetrahedron | en |
dc.identifier.volume | 71 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 233 | - |
dc.identifier.epage | 244 | - |
dc.relation.doi | 10.1016/j.tet.2014.11.065 | - |
dc.textversion | author | - |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dc.address | Graduate School of Pharmaceutical Sciences, Kyoto University | en |
dcterms.accessRights | open access | - |
datacite.date.available | 2017-01-14 | - |
datacite.awardNumber | 25293002 | - |
dc.identifier.pissn | 0040-4020 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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